Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 4797024..4797631 | Replicon | chromosome |
| Accession | NZ_CP090792 | ||
| Organism | Enterobacter hormaechei strain FY-1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A2J0PXG2 |
| Locus tag | L0Y16_RS23080 | Protein ID | WP_071788668.1 |
| Coordinates | 4797446..4797631 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A8H9RQ79 |
| Locus tag | L0Y16_RS23075 | Protein ID | WP_032651934.1 |
| Coordinates | 4797024..4797431 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y16_RS23045 (L0Y16_23045) | 4792865..4793518 | + | 654 | WP_023295601.1 | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD | - |
| L0Y16_RS23050 (L0Y16_23050) | 4793521..4794381 | + | 861 | WP_017693794.1 | L-ribulose-5-phosphate 3-epimerase | - |
| L0Y16_RS23055 (L0Y16_23055) | 4794375..4795070 | + | 696 | WP_017382588.1 | L-ribulose-5-phosphate 4-epimerase | - |
| L0Y16_RS23060 (L0Y16_23060) | 4795071..4795358 | - | 288 | Protein_4512 | helix-turn-helix domain-containing protein | - |
| L0Y16_RS23065 (L0Y16_23065) | 4795353..4795742 | + | 390 | Protein_4513 | glycoside hydrolase family 127 protein | - |
| L0Y16_RS23070 (L0Y16_23070) | 4795944..4797020 | + | 1077 | WP_032651932.1 | type I restriction enzyme HsdR N-terminal domain-containing protein | - |
| L0Y16_RS23075 (L0Y16_23075) | 4797024..4797431 | - | 408 | WP_032651934.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| L0Y16_RS23080 (L0Y16_23080) | 4797446..4797631 | - | 186 | WP_071788668.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| L0Y16_RS23085 (L0Y16_23085) | 4797881..4799419 | - | 1539 | WP_032651936.1 | aldehyde dehydrogenase AldB | - |
| L0Y16_RS23090 (L0Y16_23090) | 4799586..4800470 | + | 885 | WP_032651938.1 | ROK family protein | - |
| L0Y16_RS23095 (L0Y16_23095) | 4800474..4802312 | - | 1839 | WP_032651940.1 | selenocysteine-specific translation elongation factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6822.05 Da Isoelectric Point: 11.5191
>T231911 WP_071788668.1 NZ_CP090792:c4797631-4797446 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH
Download Length: 186 bp
>T231911 NZ_CP126994:c1810122-1809682 [Acidisoma sp. PAMC 29798]
ATGCTGGCGTGGAGGATTTGCCGAAAGCCTTTCGCTGATATCGGGGGTGACGGGGCGCGGCTCTATGGGGGCCGCTGGAA
TACGCCCGGACGCCCGGTTCTCTATTGTGGATCGACAGCGGCACTCGCCGTCCTGGAAGTCCGCGTGCATCTTGATCTGC
CGCCTGAACTTCTGCCTGCCGATTATGTTCTGATGACGATAGATCTCAACGACTTGGCCATCGAGGATGTCATGTCTTGG
CCGTCCAACCCGCAGGCCTTTGGTGACGAGTGGCTGCGTGACCAGCGAACGCCCTTGCTGAGGGTTCCATCCGCAATCGT
GCCCGAAAGCACGAACATCGTTCTCAATGTCGCTCATCCTGCAGCGGCAGGCGCCGCCATCGTCGAGATCCGCCCGTTCG
CCTTCGACCAACGCCTCTGGCTACCGCTCCGCCCGGCGTAG
ATGCTGGCGTGGAGGATTTGCCGAAAGCCTTTCGCTGATATCGGGGGTGACGGGGCGCGGCTCTATGGGGGCCGCTGGAA
TACGCCCGGACGCCCGGTTCTCTATTGTGGATCGACAGCGGCACTCGCCGTCCTGGAAGTCCGCGTGCATCTTGATCTGC
CGCCTGAACTTCTGCCTGCCGATTATGTTCTGATGACGATAGATCTCAACGACTTGGCCATCGAGGATGTCATGTCTTGG
CCGTCCAACCCGCAGGCCTTTGGTGACGAGTGGCTGCGTGACCAGCGAACGCCCTTGCTGAGGGTTCCATCCGCAATCGT
GCCCGAAAGCACGAACATCGTTCTCAATGTCGCTCATCCTGCAGCGGCAGGCGCCGCCATCGTCGAGATCCGCCCGTTCG
CCTTCGACCAACGCCTCTGGCTACCGCTCCGCCCGGCGTAG
Antitoxin
Download Length: 136 a.a. Molecular weight: 15110.90 Da Isoelectric Point: 4.3197
>AT231911 WP_032651934.1 NZ_CP090792:c4797431-4797024 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR
Download Length: 408 bp
>AT231911 NZ_CP126994:c1810551-1810132 [Acidisoma sp. PAMC 29798]
ATGAGCGTTTTCGAGGTTGTCGGTGGCGTTGCCGTCATGGGCAGCGATGTGGCTCCCGGCCTCGACACCGTAACGCGCGT
GCGCCGCGGCCTTCCTGTTGCAGCCGTTCAATTCCTGCTCGACACCGGCAAACTGACGCTCGCTGAGCTAGACAAGATTG
TTATGCCTCGGAAGACTTTGGCAAATCGACGGAAGCTCGGGACGCTGACGGCCGAACAATCCGATCGGCTGATACGAGTG
GCTCGCATCTTGGCAAGCGCCGAGGAAACCTTTGGCGATCGGGACAAAGCTGGAATTTGGCTGCGGCGACCGACGACGGC
ACTGGCGGGCGAACAGCCCCTGTCATTGCTCGATACCGATGAAGGGACGCGAGAGGTTGAGCGTCTACTCGGGCGCATTG
ATCATGGTTTGGCGGCCTGA
ATGAGCGTTTTCGAGGTTGTCGGTGGCGTTGCCGTCATGGGCAGCGATGTGGCTCCCGGCCTCGACACCGTAACGCGCGT
GCGCCGCGGCCTTCCTGTTGCAGCCGTTCAATTCCTGCTCGACACCGGCAAACTGACGCTCGCTGAGCTAGACAAGATTG
TTATGCCTCGGAAGACTTTGGCAAATCGACGGAAGCTCGGGACGCTGACGGCCGAACAATCCGATCGGCTGATACGAGTG
GCTCGCATCTTGGCAAGCGCCGAGGAAACCTTTGGCGATCGGGACAAAGCTGGAATTTGGCTGCGGCGACCGACGACGGC
ACTGGCGGGCGAACAGCCCCTGTCATTGCTCGATACCGATGAAGGGACGCGAGAGGTTGAGCGTCTACTCGGGCGCATTG
ATCATGGTTTGGCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|