Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2447196..2447935 Replicon chromosome
Accession NZ_CP090792
Organism Enterobacter hormaechei strain FY-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A7T9PDC6
Locus tag L0Y16_RS11825 Protein ID WP_032653599.1
Coordinates 2447196..2447681 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag L0Y16_RS11830 Protein ID WP_003857131.1
Coordinates 2447669..2447935 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y16_RS11795 (L0Y16_11795) 2442693..2443307 + 615 WP_080337332.1 NUDIX hydrolase -
L0Y16_RS11800 (L0Y16_11800) 2443491..2444126 - 636 WP_015570517.1 DUF421 domain-containing protein -
L0Y16_RS11805 (L0Y16_11805) 2444136..2444582 - 447 WP_032653595.1 DUF3290 domain-containing protein -
L0Y16_RS11810 (L0Y16_11810) 2445011..2445339 - 329 Protein_2307 ISNCY family transposase -
L0Y16_RS11815 (L0Y16_11815) 2445595..2446560 + 966 WP_032648329.1 hypothetical protein -
L0Y16_RS11820 (L0Y16_11820) 2446576..2447145 + 570 WP_032648331.1 hypothetical protein -
L0Y16_RS11825 (L0Y16_11825) 2447196..2447681 - 486 WP_032653599.1 GNAT family N-acetyltransferase Toxin
L0Y16_RS11830 (L0Y16_11830) 2447669..2447935 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
L0Y16_RS11835 (L0Y16_11835) 2447999..2448928 - 930 WP_032653603.1 LysR family transcriptional regulator -
L0Y16_RS11840 (L0Y16_11840) 2449058..2450446 + 1389 WP_032653606.1 MFS transporter -
L0Y16_RS11845 (L0Y16_11845) 2450469..2451464 - 996 WP_017382342.1 DUF2891 domain-containing protein -
L0Y16_RS11850 (L0Y16_11850) 2451474..2452460 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17539.29 Da        Isoelectric Point: 10.3883

>T231899 WP_032653599.1 NZ_CP090792:c2447681-2447196 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGKAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T231899 NZ_CP126992:63745-64023 [Pseudomonas syringae pv. antirrhini str. 126]
ATGATTGTGAGTTTTAAGTGCGTGAACACGAGATATCTCTTTTTACAAGGCAAGACGCGGCTGTGGCCATCGATTAAATC
TGTTGCCGAGCGCAAGCTCGCAATGCTTGATGCTGCTACCTCGATTTTGGATCTGCGCTCTCCTCCCGGCAATCGACTAG
AGGCGCTTGATGGAAGTCGTTCTGGCCAATACAGCGTACGTATAAACGCTCAATTCAGGATTTGCTTCGTTTGGAGCATC
AACGGTCCCGAGGACGTAGAAATTGTCGATTATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT231899 WP_003857131.1 NZ_CP090792:c2447935-2447669 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT231899 NZ_CP126992:64033-64338 [Pseudomonas syringae pv. antirrhini str. 126]
ATGAACAAAAACGGAATGCGCCCCGTCCATCCAGGCGAGGTTCTGAAAGAGGAATATCTTGAGCCGATGGGGCTGACCGC
CGCAGCGTTGGCCAGGGCCCTTAAGGTTTCTACGCCGACGGTGAACGACATCGTGCTCCAGCGCAGAGGTGTGAGCGCTG
ATGTAGCGCTGCGTCTGGCTGTATGCCTGGAGACGAGTCCTGAGTTCTGGCTTAACCTGCAGCTTGCCTACGATCTGCGC
AAGGCAGAGACAGAGAAGGGCGCGCAGATTCGTGAGCAGGTCAAATGTCTGGCCCACTGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9PDC6

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References