Detailed information of TA system TA231894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 367807..368393
• Replicon: chromosome
• Accession: NZ_CP090790
• Organism: Bifidobacterium longum strain D2TC

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A083XX11
• Locus tag: LMY38_RS01840
• Protein ID: WP_032683781.1
• Coordinates: 367807..368112 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LMY38_RS01845
• Protein ID: WP_007051863.1
• Coordinates: 368109..368393 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMY38_RS01775 (LMY38_01775)	363165..363377	+	213	WP_032683792.1	hypothetical protein	-
LMY38_RS01780 (LMY38_01780)	363367..363966	+	600	WP_050494256.1	hypothetical protein	-
LMY38_RS01785 (LMY38_01785)	363963..364385	+	423	WP_032683791.1	hypothetical protein	-
LMY38_RS01790 (LMY38_01790)	364382..364675	+	294	WP_032683790.1	hypothetical protein	-
LMY38_RS01795 (LMY38_01795)	364672..364917	+	246	WP_032683789.1	hypothetical protein	-
LMY38_RS01800 (LMY38_01800)	364967..365224	+	258	WP_032683788.1	hypothetical protein	-
LMY38_RS01805 (LMY38_01805)	365468..365659	+	192	WP_032683787.1	hypothetical protein	-
LMY38_RS01810 (LMY38_01810)	365696..365938	+	243	WP_032683786.1	hypothetical protein	-
LMY38_RS01815 (LMY38_01815)	365935..366216	+	282	WP_032683784.1	hypothetical protein	-
LMY38_RS01820 (LMY38_01820)	366213..366491	+	279	WP_023658290.1	hypothetical protein	-
LMY38_RS01825 (LMY38_01825)	366488..366700	+	213	WP_032683783.1	hypothetical protein	-
LMY38_RS01830 (LMY38_01830)	366697..366885	+	189	WP_032683782.1	hypothetical protein	-
LMY38_RS01835 (LMY38_01835)	366999..367775	+	777	WP_231938199.1	hypothetical protein	-
LMY38_RS01840 (LMY38_01840)	367807..368112	+	306	WP_032683781.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LMY38_RS01845 (LMY38_01845)	368109..368393	+	285	WP_007051863.1	putative addiction module antidote protein	Antitoxin
LMY38_RS01860 (LMY38_01860)	368716..368925	+	210	WP_131187342.1	hypothetical protein	-
LMY38_RS01865 (LMY38_01865)	368884..369393	-	510	WP_032683780.1	hypothetical protein	-
LMY38_RS01870 (LMY38_01870)	369383..369592	-	210	WP_032683779.1	hypothetical protein	-
LMY38_RS01875 (LMY38_01875)	369582..369758	-	177	WP_155272922.1	hypothetical protein	-
LMY38_RS01880 (LMY38_01880)	370341..370595	+	255	WP_032683778.1	hypothetical protein	-
LMY38_RS01885 (LMY38_01885)	370688..371050	+	363	WP_032683777.1	hypothetical protein	-
LMY38_RS01890 (LMY38_01890)	371063..372682	+	1620	WP_032683776.1	terminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	335177..392378	57201

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (11-94)

Antitoxin

• Uncharacterized protein HI1420 (4-91)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11456.24 Da
• Isoelectric Point: 10.3171

>T231894 WP_032683781.1 NZ_CP090790:367807-368112 [Bifidobacterium longum]
MEIKQTAEYRKWFKKLRNREAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHIGAGYRVYFTTRGNVLMLLLAGGDK
STQQTDIKQAHAILDDYKEQQ

Nucleotide

• Length: 306 bp

>T231894 NZ_CP126987:c4632584-4632051 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10124.35 Da
• Isoelectric Point: 4.3707

>AT231894 WP_007051863.1 NZ_CP090790:368109-368393 [Bifidobacterium longum]
MSTEITDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Nucleotide

• Length: 285 bp

>AT231894 NZ_CP126987:c4632861-4632595 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A083XX11