Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 40124..40782 Replicon plasmid p1_2003Ycf867
Accession NZ_CP090789
Organism Burkholderia vietnamiensis strain 2003Ycf867

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DW07
Locus tag L0Y95_RS29255 Protein ID WP_060081729.1
Coordinates 40124..40555 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B4LJE8
Locus tag L0Y95_RS29260 Protein ID WP_043292778.1
Coordinates 40555..40782 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y95_RS29230 (L0Y95_29230) 36675..37253 - 579 WP_060081731.1 hypothetical protein -
L0Y95_RS29235 (L0Y95_29235) 37269..38363 - 1095 WP_230973099.1 DUF3396 domain-containing protein -
L0Y95_RS29240 (L0Y95_29240) 38363..39127 - 765 WP_060081730.1 VRR-NUC domain-containing protein -
L0Y95_RS29245 (L0Y95_29245) 39124..39654 - 531 WP_060081734.1 PAAR domain-containing protein -
L0Y95_RS29250 (L0Y95_29250) 39775..40101 - 327 WP_176290496.1 hypothetical protein -
L0Y95_RS29255 (L0Y95_29255) 40124..40555 - 432 WP_060081729.1 PIN domain-containing protein Toxin
L0Y95_RS29260 (L0Y95_29260) 40555..40782 - 228 WP_043292778.1 hypothetical protein Antitoxin
L0Y95_RS29265 (L0Y95_29265) 41139..42341 + 1203 WP_063900352.1 hypothetical protein -
L0Y95_RS29270 (L0Y95_29270) 42441..42992 + 552 WP_060081727.1 hypothetical protein -
L0Y95_RS29275 (L0Y95_29275) 43300..44010 - 711 WP_060081726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73850 73850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15573.85 Da        Isoelectric Point: 7.2342

>T231892 WP_060081729.1 NZ_CP090789:c40555-40124 [Burkholderia vietnamiensis]
MAYLLDVNVLIALLDPAHVQHEPAHAWFGRVGHSAWATCPLTENGVLRIIGNPKYPNTMGSPASVAPLVAQLRSHTGHTF
WSDDVSLLDEKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPNGAKHLELIS

Download         Length: 432 bp

>T231892 NZ_CP126987:c2741120-2739798 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8080.14 Da        Isoelectric Point: 8.9793

>AT231892 WP_043292778.1 NZ_CP090789:c40782-40555 [Burkholderia vietnamiensis]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRGTTNQSSRNGLPLMPVSATARPVTLDTVNQLRDDSL

Download         Length: 228 bp

>AT231892 NZ_CP126987:c2741386-2741120 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DW07

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LJE8

References