Detailed information of TA system TA231890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3198274..3198902
• Replicon: chromosome
• Accession: NZ_CP090786
• Organism: Burkholderia vietnamiensis strain 2003Ycf867

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1B4LE75
• Locus tag: L0Y95_RS14830
• Protein ID: WP_059735504.1
• Coordinates: 3198274..3198675 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: L0Y95_RS14835
• Protein ID: WP_249471293.1
• Coordinates: 3198675..3198902 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y95_RS14820 (L0Y95_14820)	3195651..3196787	+	1137	WP_045578623.1	alginate lyase family protein	-
L0Y95_RS14825 (L0Y95_14825)	3196818..3198206	+	1389	WP_059568060.1	L-serine ammonia-lyase	-
L0Y95_RS14830 (L0Y95_14830)	3198274..3198675	-	402	WP_059735504.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Y95_RS14835 (L0Y95_14835)	3198675..3198902	-	228	WP_249471293.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Y95_RS14840 (L0Y95_14840)	3199181..3200884	+	1704	WP_059669504.1	thiamine pyrophosphate-binding protein	-
L0Y95_RS14845 (L0Y95_14845)	3200881..3202002	+	1122	WP_069246102.1	ADP-heptose--LPS heptosyltransferase	-
L0Y95_RS14850 (L0Y95_14850)	3202249..3203283	-	1035	WP_034192975.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14850.01 Da
• Isoelectric Point: 5.6350

>T231890 WP_059735504.1 NZ_CP090786:c3198675-3198274 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAALEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T231890 NZ_CP126987:1470999-1471481 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8675.72 Da
• Isoelectric Point: 5.1585

>AT231890 WP_249471293.1 NZ_CP090786:c3198902-3198675 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLEKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 228 bp

>AT231890 NZ_CP126987:1470745-1471011 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCTTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: A0A1B4LE75