Detailed information of TA system TA231887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2029516..2030097
• Replicon: chromosome
• Accession: NZ_CP090782
• Organism: Burkholderia multivorans strain 2004Ycf1069VI

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L0Y94_RS22335
• Protein ID: WP_035946056.1
• Coordinates: 2029516..2029809 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J4SGI3
• Locus tag: L0Y94_RS22340
• Protein ID: WP_006409266.1
• Coordinates: 2029813..2030097 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y94_RS22315 (L0Y94_22315)	2025005..2026105	-	1101	WP_006404967.1	chorismate synthase	-
L0Y94_RS22320 (L0Y94_22320)	2026274..2028208	-	1935	WP_006404968.1	MFS transporter	-
L0Y94_RS22325 (L0Y94_22325)	2028357..2028812	-	456	WP_006402096.1	CBS domain-containing protein	-
L0Y94_RS22330 (L0Y94_22330)	2028973..2029290	+	318	WP_006402097.1	DUF962 domain-containing protein	-
L0Y94_RS22335 (L0Y94_22335)	2029516..2029809	+	294	WP_035946056.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y94_RS22340 (L0Y94_22340)	2029813..2030097	+	285	WP_006409266.1	putative addiction module antidote protein	Antitoxin
L0Y94_RS22345 (L0Y94_22345)	2030181..2030369	+	189	WP_006409259.1	hypothetical protein	-
L0Y94_RS22350 (L0Y94_22350)	2030533..2031861	-	1329	WP_045594112.1	YihY family inner membrane protein	-
L0Y94_RS22355 (L0Y94_22355)	2032006..2032617	+	612	WP_006402099.1	NAD(P)H:quinone oxidoreductase	-
L0Y94_RS22360 (L0Y94_22360)	2032614..2033009	+	396	WP_006404970.1	DUF2069 domain-containing protein	-
L0Y94_RS22365 (L0Y94_22365)	2033028..2034449	+	1422	WP_043279886.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-88)

Antitoxin

• Uncharacterized protein HI1420 (5-90)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11168.92 Da
• Isoelectric Point: 9.4615

>T231887 WP_035946056.1 NZ_CP090782:2029516-2029809 [Burkholderia multivorans]
MVTLLRSTEFNDWLANLRDQRGKARIAARLISAQLGNFGEYRVLDEGVCELKIDFGPGYRVYYVRRGEVVYLLLCGGDKS
TQRKDIKPVQMARELKE

Nucleotide

• Length: 294 bp

>T231887 NZ_CP126987:357105-357452 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9986.38 Da
• Isoelectric Point: 6.2121

>AT231887 WP_006409266.1 NZ_CP090782:2029813-2030097 [Burkholderia multivorans]
MTNYTEFDAADYLDNDEAVAEFLAVAAEDPNPDVFLAAVAAVARARGMTKVAAAAGVGRVALHKALTPGAHPRYETVQKI
IRSLGLRMSFTVAH

Nucleotide

• Length: 285 bp

>AT231887 NZ_CP126987:357452-357751 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: J4SGI3