Detailed information of TA system TA231886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 995684..996384
• Replicon: chromosome
• Accession: NZ_CP090782
• Organism: Burkholderia multivorans strain 2004Ycf1069VI

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9BQB7
• Locus tag: L0Y94_RS17395
• Protein ID: WP_006405634.1
• Coordinates: 996007..996384 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Y94_RS17390
• Protein ID: WP_006405635.1
• Coordinates: 995684..996007 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y94_RS17370 (L0Y94_17370)	991033..992493	+	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-
L0Y94_RS17375 (L0Y94_17375)	992652..994550	+	1899	WP_006409758.1	molecular chaperone HtpG	-
L0Y94_RS17380 (L0Y94_17380)	994559..995173	+	615	WP_006398690.1	chorismate lyase	-
L0Y94_RS17385 (L0Y94_17385)	995170..995661	+	492	WP_006409760.1	DNA-deoxyinosine glycosylase	-
L0Y94_RS17390 (L0Y94_17390)	995684..996007	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y94_RS17395 (L0Y94_17395)	996007..996384	-	378	WP_006405634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y94_RS17400 (L0Y94_17400)	996913..997167	-	255	WP_035488690.1	hypothetical protein	-
L0Y94_RS17405 (L0Y94_17405)	997395..998312	+	918	WP_006405631.1	spermidine synthase	-
L0Y94_RS17410 (L0Y94_17410)	998509..998742	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Y94_RS17415 (L0Y94_17415)	998739..1000289	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Y94_RS17420 (L0Y94_17420)	1000393..1000839	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13564.63 Da
• Isoelectric Point: 9.7722

>T231886 WP_006405634.1 NZ_CP090782:c996384-996007 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231886 NZ_CP126987:331136-331504 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231886 WP_006405635.1 NZ_CP090782:c996007-995684 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231886 NZ_CP126987:330918-331139 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: B9BQB7

Antitoxin

• AlphaFold DB: B9BQB8