Detailed information of TA system TA231885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1727702..1728972
• Replicon: chromosome
• Accession: NZ_CP090781
• Organism: Burkholderia multivorans strain 2004Ycf1069VI

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Y94_RS10015
• Protein ID: WP_006410613.1
• Coordinates: 1728394..1728972 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9BS12
• Locus tag: L0Y94_RS10010
• Protein ID: WP_006406126.1
• Coordinates: 1727702..1728259 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y94_RS09990 (L0Y94_09990)	1722998..1724023	+	1026	WP_006406131.1	aldo/keto reductase	-
L0Y94_RS09995 (L0Y94_09995)	1724123..1724566	+	444	WP_223852633.1	antibiotic biosynthesis monooxygenase	-
L0Y94_RS10000 (L0Y94_10000)	1725155..1725775	+	621	WP_006410617.1	isochorismatase family cysteine hydrolase	-
L0Y94_RS10005 (L0Y94_10005)	1725786..1727189	-	1404	WP_006406128.1	hypothetical protein	-
L0Y94_RS10010 (L0Y94_10010)	1727702..1728259	+	558	WP_006406126.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y94_RS10015 (L0Y94_10015)	1728394..1728972	+	579	WP_006410613.1	HD domain-containing protein	Toxin
L0Y94_RS10020 (L0Y94_10020)	1729073..1730611	-	1539	WP_006410596.1	MFS transporter	-
L0Y94_RS10025 (L0Y94_10025)	1730790..1731710	+	921	WP_006406123.1	LysR family transcriptional regulator	-
L0Y94_RS10030 (L0Y94_10030)	1731757..1732896	-	1140	WP_006410588.1	enoyl-CoA hydratase/isomerase family protein	-
L0Y94_RS10035 (L0Y94_10035)	1732893..1733684	-	792	WP_035947285.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21384.10 Da
• Isoelectric Point: 4.9434

>T231885 WP_006410613.1 NZ_CP090781:1728394-1728972 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T231885 NZ_CP126986:c1080808-1080062 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20378.30 Da
• Isoelectric Point: 7.8341

>AT231885 WP_006406126.1 NZ_CP090781:1727702-1728259 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT231885 NZ_CP126986:c1080061-1079891 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Antitoxin

• AlphaFold DB: B9BS12