Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1566798..1567387 Replicon chromosome
Accession NZ_CP090781
Organism Burkholderia multivorans strain 2004Ycf1069VI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y94_RS09345 Protein ID WP_006409935.1
Coordinates 1566798..1567217 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y94_RS09350 Protein ID WP_174328801.1
Coordinates 1567214..1567387 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y94_RS09320 (L0Y94_09320) 1561873..1562667 + 795 WP_006409930.1 AraC family transcriptional regulator -
L0Y94_RS09325 (L0Y94_09325) 1563180..1564130 + 951 WP_172488721.1 DMT family transporter -
L0Y94_RS09330 (L0Y94_09330) 1564334..1564909 + 576 WP_006409927.1 hypothetical protein -
L0Y94_RS09335 (L0Y94_09335) 1565003..1565137 - 135 WP_006409923.1 entericidin A/B family lipoprotein -
L0Y94_RS09340 (L0Y94_09340) 1565370..1566665 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Y94_RS09345 (L0Y94_09345) 1566798..1567217 - 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y94_RS09350 (L0Y94_09350) 1567214..1567387 - 174 WP_174328801.1 plasmid stability protein Antitoxin
L0Y94_RS09355 (L0Y94_09355) 1567671..1569917 + 2247 WP_006403070.1 TonB-dependent siderophore receptor -
L0Y94_RS09360 (L0Y94_09360) 1569921..1570676 + 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Y94_RS09365 (L0Y94_09365) 1570673..1571356 + 684 WP_006409924.1 Fe2+-dependent dioxygenase -
L0Y94_RS09370 (L0Y94_09370) 1571370..1571573 - 204 WP_006403067.1 hypothetical protein -
L0Y94_RS09375 (L0Y94_09375) 1572162..1572305 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T231884 WP_006409935.1 NZ_CP090781:c1567217-1566798 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T231884 NZ_CP126986:328938-329288 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6298.07 Da        Isoelectric Point: 4.5184

>AT231884 WP_174328801.1 NZ_CP090781:c1567387-1567214 [Burkholderia multivorans]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 174 bp

>AT231884 NZ_CP126986:328651-328932 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References