Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1131531..1132065 Replicon chromosome
Accession NZ_CP090781
Organism Burkholderia multivorans strain 2004Ycf1069VI

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag L0Y94_RS07510 Protein ID WP_006411826.1
Coordinates 1131766..1132065 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B9B0C2
Locus tag L0Y94_RS07505 Protein ID WP_006397060.1
Coordinates 1131531..1131776 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y94_RS07490 (L0Y94_07490) 1126582..1128285 + 1704 WP_006411824.1 VRR-NUC domain-containing protein -
L0Y94_RS07495 (L0Y94_07495) 1128282..1130582 + 2301 WP_006411821.1 ATP-dependent DNA helicase -
L0Y94_RS07500 (L0Y94_07500) 1130621..1131391 - 771 WP_006403543.1 IclR family transcriptional regulator C-terminal domain-containing protein -
L0Y94_RS07505 (L0Y94_07505) 1131531..1131776 + 246 WP_006397060.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
L0Y94_RS07510 (L0Y94_07510) 1131766..1132065 + 300 WP_006411826.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y94_RS07515 (L0Y94_07515) 1132174..1133475 - 1302 WP_006403538.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
L0Y94_RS07520 (L0Y94_07520) 1133699..1135006 - 1308 WP_006411823.1 shikimate transporter -
L0Y94_RS07525 (L0Y94_07525) 1135361..1136488 + 1128 WP_006403536.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11585.15 Da        Isoelectric Point: 9.3671

>T231882 WP_006411826.1 NZ_CP090781:1131766-1132065 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T231882 NZ_CP126980:8993664-8994029 [Actinoplanes sp. NRRL 3884]
GTGAAAGAATGGGAGATCTTCGCAACCGACGAGTTCTATGCCTGGGCAGACACTCTTGATCGGGCATCGCTGAGACATCT
CGTGCAAGCCATTGATCAGCTCGCTGAGGTGGGCCCGGGATTGGGACGACCACTCGTCGACCACATCGAGGGTTCACGGG
TGCACAACATGAAGGAGCTACGGCCCGGTTCATCGGGACGGAGCGAGATTCGTGCCCTTTTCGTCTTCGACCCCTGGCGA
TCAACGATCCTGCTCATCGGCGGAGACAAGTCTGGTAACTGGTCCGGGTGGTATCGCACGGCGATCCCGGCGGCCGAGGA
GTTGTACGCGCGGTACCTGAAGGACCGCCAGAACGAGGAGGCGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8662.73 Da        Isoelectric Point: 6.4604

>AT231882 WP_006397060.1 NZ_CP090781:1131531-1131776 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT231882 NZ_CP126980:8994032-8994370 [Actinoplanes sp. NRRL 3884]
GTGCCCGGATACCACAAGTGGAGCGACATCCGAGCCGAATTCGTCGAGAAGGCCGGCGGCGAGGAGGCCATCGCTGAGGC
GCGCCGGCAGAGTCAGGCGTATGTCAACGGATACCGACTGGCTGAGCGACGGAAGTCGATCGGGCTGACCCAGGCCGAGG
TCGCCGAACGGATGGGCGTGACCAAGGGCCGAGTCTCCCAGATCGAGCGTGGCGAGGTCGCCACCGTCGACGCCATCGCC
CGCTACGTCCACGCGCTCGGGGGCTACCTCCAGATCTCCGCCGTTTTCGGCGACGACCAGTACATCCTGCGCGGCACCGA
CCCGCAGGCCGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9B0C2

References