Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 996080..997119 | Replicon | chromosome |
| Accession | NZ_CP090781 | ||
| Organism | Burkholderia multivorans strain 2004Ycf1069VI | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | L0Y94_RS06885 | Protein ID | WP_045593318.1 |
| Coordinates | 996544..997119 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A8B3VE28 |
| Locus tag | L0Y94_RS06880 | Protein ID | WP_035946227.1 |
| Coordinates | 996080..996547 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y94_RS06855 (L0Y94_06855) | 991550..993013 | + | 1464 | WP_006409448.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
| L0Y94_RS06860 (L0Y94_06860) | 993056..993904 | + | 849 | WP_006409439.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Y94_RS06865 (L0Y94_06865) | 993940..994332 | + | 393 | WP_006409445.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Y94_RS06870 (L0Y94_06870) | 994347..995150 | + | 804 | WP_006402377.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Y94_RS06875 (L0Y94_06875) | 995158..995964 | + | 807 | WP_035487732.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Y94_RS06880 (L0Y94_06880) | 996080..996547 | + | 468 | WP_035946227.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Y94_RS06885 (L0Y94_06885) | 996544..997119 | + | 576 | WP_045593318.1 | PIN domain-containing protein | Toxin |
| L0Y94_RS06890 (L0Y94_06890) | 997364..998173 | - | 810 | WP_006409450.1 | helix-turn-helix transcriptional regulator | - |
| L0Y94_RS06895 (L0Y94_06895) | 998269..998520 | + | 252 | WP_006409444.1 | hypothetical protein | - |
| L0Y94_RS06900 (L0Y94_06900) | 998599..999564 | + | 966 | WP_006409441.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Y94_RS06905 (L0Y94_06905) | 999623..999736 | - | 114 | Protein_894 | porin | - |
| L0Y94_RS06910 (L0Y94_06910) | 999747..999929 | + | 183 | WP_249456323.1 | hypothetical protein | - |
| L0Y94_RS06915 (L0Y94_06915) | 1000120..1001178 | + | 1059 | WP_226823145.1 | DUF6402 family protein | - |
| L0Y94_RS06920 (L0Y94_06920) | 1001192..1001692 | + | 501 | WP_226823143.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21555.65 Da Isoelectric Point: 4.8924
>T231881 WP_045593318.1 NZ_CP090781:996544-997119 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
Download Length: 576 bp
>T231881 NZ_CP126980:c1517564-1517304 [Actinoplanes sp. NRRL 3884]
GTGAAACTCAGCTGGACCGATCACGGCTGGGACGACTACCTGTACTGGCAGACCCAGGACCGCAAGACCCTCAAACGCAT
CAACGCGCTGATCGCCGACATCAAACGTGATCCCGACGGCCAGGGCATCGGCAAACCGGAGATCCTCCGAAACAACCTCG
CAGGGCTCCGGTCCCGGCGAATCGACGACGAGCACCGCATGGTGTACGCCGTCGAGCCCAACGAGATCACCATCATCTCC
TGTCGATACCACTACGAATAG
GTGAAACTCAGCTGGACCGATCACGGCTGGGACGACTACCTGTACTGGCAGACCCAGGACCGCAAGACCCTCAAACGCAT
CAACGCGCTGATCGCCGACATCAAACGTGATCCCGACGGCCAGGGCATCGGCAAACCGGAGATCCTCCGAAACAACCTCG
CAGGGCTCCGGTCCCGGCGAATCGACGACGAGCACCGCATGGTGTACGCCGTCGAGCCCAACGAGATCACCATCATCTCC
TGTCGATACCACTACGAATAG
Antitoxin
Download Length: 156 a.a. Molecular weight: 17655.06 Da Isoelectric Point: 5.8709
>AT231881 WP_035946227.1 NZ_CP090781:996080-996547 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
Download Length: 468 bp
>AT231881 NZ_CP126980:c1517818-1517561 [Actinoplanes sp. NRRL 3884]
GTGACTTCAGCGATCAGTGCCAGCGAGGCACGCAAGTCCCTCTTTCCGCTCATCGAGCGCGTCAACGAGGACCACACCCC
GATCGAGATCGTCTCCAAGCGTGGCAACGCCGTCCTGGTGAGCAAGGAGGACTGGGATTCGATCATGGAAACCAACTACC
TGCTTCGATCGCCTGCCAACGCCAGGCACCTCGCCGAGAGCGTCGAGCAGTGGCGAGCCGGCCGAGCCACCCAGCGTGAT
TTCGGGCCCGAGGAGTGA
GTGACTTCAGCGATCAGTGCCAGCGAGGCACGCAAGTCCCTCTTTCCGCTCATCGAGCGCGTCAACGAGGACCACACCCC
GATCGAGATCGTCTCCAAGCGTGGCAACGCCGTCCTGGTGAGCAAGGAGGACTGGGATTCGATCATGGAAACCAACTACC
TGCTTCGATCGCCTGCCAACGCCAGGCACCTCGCCGAGAGCGTCGAGCAGTGGCGAGCCGGCCGAGCCACCCAGCGTGAT
TTCGGGCCCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|