Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 405105..405725 Replicon chromosome
Accession NZ_CP090781
Organism Burkholderia multivorans strain 2004Ycf1069VI

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Y94_RS04310 Protein ID WP_012217495.1
Coordinates 405408..405725 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Y94_RS04305 Protein ID WP_006398012.1
Coordinates 405105..405404 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y94_RS04280 (L0Y94_04280) 400343..401614 + 1272 WP_006411366.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Y94_RS04285 (L0Y94_04285) 401629..402117 + 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y94_RS04290 (L0Y94_04290) 402135..402461 + 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y94_RS04295 (L0Y94_04295) 402451..403671 + 1221 WP_006411378.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y94_RS04300 (L0Y94_04300) 403786..405072 + 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Y94_RS04305 (L0Y94_04305) 405105..405404 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Y94_RS04310 (L0Y94_04310) 405408..405725 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y94_RS04315 (L0Y94_04315) 406088..407728 + 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Y94_RS04320 (L0Y94_04320) 407757..409190 + 1434 WP_006404214.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231880 WP_012217495.1 NZ_CP090781:c405725-405408 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231880 NZ_CP090781:c405725-405408 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231880 WP_006398012.1 NZ_CP090781:c405404-405105 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231880 NZ_CP090781:c405404-405105 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
TTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References