Detailed information of TA system TA231879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2402602..2403302
• Replicon: chromosome
• Accession: NZ_CP090779
• Organism: Burkholderia multivorans strain 2005Ycf971III

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9BQB7
• Locus tag: L0Y92_RS23960
• Protein ID: WP_006405634.1
• Coordinates: 2402602..2402979 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Y92_RS23965
• Protein ID: WP_006405635.1
• Coordinates: 2402979..2403302 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y92_RS23935 (L0Y92_23935)	2398147..2398593	+	447	WP_006405630.1	VOC family protein	-
L0Y92_RS23940 (L0Y92_23940)	2398697..2400247	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Y92_RS23945 (L0Y92_23945)	2400244..2400477	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Y92_RS23950 (L0Y92_23950)	2400674..2401591	-	918	WP_006405631.1	spermidine synthase	-
L0Y92_RS23955 (L0Y92_23955)	2401819..2402073	+	255	WP_035488690.1	hypothetical protein	-
L0Y92_RS23960 (L0Y92_23960)	2402602..2402979	+	378	WP_006405634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y92_RS23965 (L0Y92_23965)	2402979..2403302	+	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y92_RS23970 (L0Y92_23970)	2403325..2403816	-	492	WP_006409760.1	DNA-deoxyinosine glycosylase	-
L0Y92_RS23975 (L0Y92_23975)	2403813..2404427	-	615	WP_006398690.1	chorismate lyase	-
L0Y92_RS23980 (L0Y92_23980)	2404436..2406334	-	1899	WP_006409758.1	molecular chaperone HtpG	-
L0Y92_RS23985 (L0Y92_23985)	2406493..2407953	-	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2396957..2465950	68993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13564.63 Da
• Isoelectric Point: 9.7722

>T231879 WP_006405634.1 NZ_CP090779:2402602-2402979 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231879 NZ_CP126978:c1291402-1290995 [Gallibacterium anatis]
ATGCTGAAATATATGTTGGATACCAATATCGTTATTTTTACGATAAAAAATAAGCCGCCACATTTGTTGCCGTTATTTAA
TGAAAATCAATCTATGCTTTGTATCAGCTCGATTACATTAATGGAGCTGGTTTATGGGGCAGAGAAAAGCAAAAAAACGG
CACAGAATCTTGCCGTTATTGAATCTTTCTGTGCAAGATTAGCCGTTTTGGATTATGACGAGGCAGCAGCATATCATAGT
GGGCAGATAAGAGCTGAATTAGCAAAAATTGGACAACCTATTGGACCATATGACGCAATGATCGCTGGGCACGCAAGGAG
TCTAGGCTTGACAGTTGTTACTAACAATATGAATGAGTTTTCACGGGTAGAGGGGTTAAGGGTAATCGATTGGAGTAAGC
CGATGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231879 WP_006405635.1 NZ_CP090779:2402979-2403302 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231879 NZ_CP126978:c1291641-1291402 [Gallibacterium anatis]
ATGAGTGTAGTGACCGCAACTGTTTTTATGAATAATAAAAGCCAAGCTATCAGAATTCCGAAAGCTGCAGAATTACCTAA
TACTACAAAAAGTGTAAATATCATTATTCAAGGGGATATGCGTATTATCACACCTCTCAATAATGTTTGGGACAGCTGGT
TCAATGATTCAAATTCCGTATCGGACGATTTTATGTTAAGTCGTGAGCAACCACAGATGCAGGAAAGGGAAGAATTATAA

Structures

Toxin

• AlphaFold DB: B9BQB7

Antitoxin

• AlphaFold DB: B9BQB8