Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1953531..1954151 Replicon chromosome
Accession NZ_CP090778
Organism Burkholderia multivorans strain 2005Ycf971III

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Y92_RS10720 Protein ID WP_012217495.1
Coordinates 1953531..1953848 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Y92_RS10725 Protein ID WP_006398012.1
Coordinates 1953852..1954151 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y92_RS10710 (L0Y92_10710) 1950066..1951499 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Y92_RS10715 (L0Y92_10715) 1951528..1953168 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Y92_RS10720 (L0Y92_10720) 1953531..1953848 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y92_RS10725 (L0Y92_10725) 1953852..1954151 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Y92_RS10730 (L0Y92_10730) 1954184..1955470 - 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Y92_RS10735 (L0Y92_10735) 1955585..1956805 - 1221 WP_006411378.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y92_RS10740 (L0Y92_10740) 1956795..1957121 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y92_RS10745 (L0Y92_10745) 1957139..1957627 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y92_RS10750 (L0Y92_10750) 1957642..1958913 - 1272 WP_006411366.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231876 WP_012217495.1 NZ_CP090778:1953531-1953848 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231876 NZ_CP126978:164659-164955 [Gallibacterium anatis]
ATGATTCAGATAAAATCAACAGAAACCTTTGATAAATGGCTAGATAATCTCAAGGATTTAAGGGCAAGGGCTAAAATTCA
AGTGCGGATTAAACGATTACAGCTTGGCAATTTTGGTGATGTAAAGCCGATAGGTGAAGGGTTATCTGAATTAAGAATAA
CAGAAGGGAAAGGCTACCGTCTGTACTTGAAAAATCAGAATGGGGTGATTGTGATTTTGTTATGCGGTGGTGACAAATCC
ACACAGAAAGCGGATATTGAAAAGGCAAAATCTTTAGCAAAAGAGTTAGGAGTTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231876 WP_006398012.1 NZ_CP090778:1953852-1954151 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231876 NZ_CP126978:164957-165241 [Gallibacterium anatis]
ATGGTTGAGAAATTACACGATTTTGATATGTCCGAACATTTACGCACAGAAGAAGAAATACAGCTTTATCTTAATGAGAT
TTTAAGTGAGGGTGATATTGATTTATTGCTTTCTGCGTTAGGTGATATAGCGAAAGCGAGAAATATGAGTCAAATTGCCC
GAGAAGTAGGAATAACGAGAGAAGGGTTATATAAAGCGCTTTCTGGGCGAGGCAATCCCACATTTGCCACTGTGTTTAAG
GTCATGCAGGCGTTAAACTTGAATTTAGAAGTAAAACACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References