Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1362137..1363176 | Replicon | chromosome |
| Accession | NZ_CP090778 | ||
| Organism | Burkholderia multivorans strain 2005Ycf971III | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | L0Y92_RS08145 | Protein ID | WP_045593318.1 |
| Coordinates | 1362137..1362712 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A8B3VE28 |
| Locus tag | L0Y92_RS08150 | Protein ID | WP_035946227.1 |
| Coordinates | 1362709..1363176 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y92_RS08110 (L0Y92_08110) | 1357564..1358064 | - | 501 | WP_226823143.1 | hypothetical protein | - |
| L0Y92_RS08115 (L0Y92_08115) | 1358078..1359136 | - | 1059 | WP_226823145.1 | DUF6402 family protein | - |
| L0Y92_RS08120 (L0Y92_08120) | 1359327..1359509 | - | 183 | WP_249456323.1 | hypothetical protein | - |
| L0Y92_RS08125 (L0Y92_08125) | 1359520..1359633 | + | 114 | Protein_1134 | porin | - |
| L0Y92_RS08130 (L0Y92_08130) | 1359692..1360657 | - | 966 | WP_006409441.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Y92_RS08135 (L0Y92_08135) | 1360736..1360987 | - | 252 | WP_006409444.1 | hypothetical protein | - |
| L0Y92_RS08140 (L0Y92_08140) | 1361083..1361892 | + | 810 | WP_006409450.1 | helix-turn-helix transcriptional regulator | - |
| L0Y92_RS08145 (L0Y92_08145) | 1362137..1362712 | - | 576 | WP_045593318.1 | PIN domain-containing protein | Toxin |
| L0Y92_RS08150 (L0Y92_08150) | 1362709..1363176 | - | 468 | WP_035946227.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Y92_RS08155 (L0Y92_08155) | 1363292..1364098 | - | 807 | WP_035487732.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Y92_RS08160 (L0Y92_08160) | 1364106..1364909 | - | 804 | WP_006402377.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Y92_RS08165 (L0Y92_08165) | 1364924..1365316 | - | 393 | WP_006409445.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Y92_RS08170 (L0Y92_08170) | 1365352..1366200 | - | 849 | WP_006409439.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Y92_RS08175 (L0Y92_08175) | 1366243..1367706 | - | 1464 | WP_006409448.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21555.65 Da Isoelectric Point: 4.8924
>T231875 WP_045593318.1 NZ_CP090778:c1362712-1362137 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
Download Length: 576 bp
>T231875 NZ_CP126978:c140552-140193 [Gallibacterium anatis]
ATGGCTGTAAATCATCAGTGGAATATTCTTTTTACAGATTGTTTTTCAAAGTGGCTTGATCAACAGGATATTCCAACAAA
GAAAAGTGTTGCTGCTGCACTCAATCTATTAAAAATAACTGGTCCTGAACTATCTCGTCCCTATGCGGACACGATTAAAG
GATCACAATATCCCAATATGAAAGAGTTACGCATACAACATCAAGGCAAACCTTTAAGGGCGTTTTTTGCATTTGATCCA
TTACGTCAAGCCATTGTGCTATGTGCCGGTGATAAAAGTAACGATAAACAGTTTTACAAACGAATGATTGCATTGGCAGA
TACTGAATTCGCTGCTTATTTAGCAAACTTGGAGAAATAA
ATGGCTGTAAATCATCAGTGGAATATTCTTTTTACAGATTGTTTTTCAAAGTGGCTTGATCAACAGGATATTCCAACAAA
GAAAAGTGTTGCTGCTGCACTCAATCTATTAAAAATAACTGGTCCTGAACTATCTCGTCCCTATGCGGACACGATTAAAG
GATCACAATATCCCAATATGAAAGAGTTACGCATACAACATCAAGGCAAACCTTTAAGGGCGTTTTTTGCATTTGATCCA
TTACGTCAAGCCATTGTGCTATGTGCCGGTGATAAAAGTAACGATAAACAGTTTTACAAACGAATGATTGCATTGGCAGA
TACTGAATTCGCTGCTTATTTAGCAAACTTGGAGAAATAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17655.06 Da Isoelectric Point: 5.8709
>AT231875 WP_035946227.1 NZ_CP090778:c1363176-1362709 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
Download Length: 468 bp
>AT231875 NZ_CP126978:c140191-139892 [Gallibacterium anatis]
ATGAAAACATTTGATCAATTCTTAGATGAATTTTCCCCCGAAGATCGCAAAGACATAGAAAGAATGACTGATGAACTGCT
ATTGGAATCAGGTCTTTCACTTATTCGCCAAGAAATGGAAATTTCACAAAAACAACTCGCAGATGCACTAGGTATTTCAC
AACCTGCTGTCGCTCAAATTGAACAACGAGGAAATGACTTACGCCTTTCTACACTCAAGCGTTATGTTGAAACAATGGGC
GGAAAGCTCAGCCTTGCGATTGATATGCCAATGGGAGAAACTCGAATCTTCAAAATTTGA
ATGAAAACATTTGATCAATTCTTAGATGAATTTTCCCCCGAAGATCGCAAAGACATAGAAAGAATGACTGATGAACTGCT
ATTGGAATCAGGTCTTTCACTTATTCGCCAAGAAATGGAAATTTCACAAAAACAACTCGCAGATGCACTAGGTATTTCAC
AACCTGCTGTCGCTCAAATTGAACAACGAGGAAATGACTTACGCCTTTCTACACTCAAGCGTTATGTTGAAACAATGGGC
GGAAAGCTCAGCCTTGCGATTGATATGCCAATGGGAGAAACTCGAATCTTCAAAATTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|