Detailed information of TA system TA231874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1227191..1227725
• Replicon: chromosome
• Accession: NZ_CP090778
• Organism: Burkholderia multivorans strain 2005Ycf971III

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Y92_RS07520
• Protein ID: WP_006411826.1
• Coordinates: 1227191..1227490 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: L0Y92_RS07525
• Protein ID: WP_006397060.1
• Coordinates: 1227480..1227725 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y92_RS07505 (L0Y92_07505)	1222768..1223895	-	1128	WP_006403536.1	VOC family protein	-
L0Y92_RS07510 (L0Y92_07510)	1224250..1225557	+	1308	WP_006411823.1	shikimate transporter	-
L0Y92_RS07515 (L0Y92_07515)	1225781..1227082	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Y92_RS07520 (L0Y92_07520)	1227191..1227490	-	300	WP_006411826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y92_RS07525 (L0Y92_07525)	1227480..1227725	-	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Y92_RS07530 (L0Y92_07530)	1227865..1228635	+	771	WP_006403543.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Y92_RS07535 (L0Y92_07535)	1228674..1230974	-	2301	WP_006411821.1	ATP-dependent DNA helicase	-
L0Y92_RS07540 (L0Y92_07540)	1230971..1232674	-	1704	WP_006411824.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11585.15 Da
• Isoelectric Point: 9.3671

>T231874 WP_006411826.1 NZ_CP090778:c1227490-1227191 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231874 NZ_CP126978:116014-116298 [Gallibacterium anatis]
ATGGTTGAGAAATTACACGATTTTGATATGTCCGAACATTTACGCACAGAAGAAGAAATACAGCTTTATCTTAATGAGAT
TTTAAGTGAGGGTGATATTGATTTATTGCTTTCTGCGTTAGGTGATATAGCGAAAGCGAGAAATATGAGTCAAATTGCCC
GAGAAGTAGGAATAACGAGAGAAGGGTTATATAAAGCGCTTTCTGGGCGAGGCAATCCCACATTTGCCACTGTGTTTAAG
GTCATGCAGGCGTTAAACTTGAATTTAGAAGTAAAACACGCTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT231874 WP_006397060.1 NZ_CP090778:c1227725-1227480 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231874 NZ_CP126978:115716-116012 [Gallibacterium anatis]
ATGATTCAGATAAAATCAACAGAAACCTTTGATAAATGGCTAGATAATCTCAAGGATTTAAGGGCAAGGGCTAAAATTCA
AGTGCGGATTAAACGATTACAGCTTGGCAATTTTGGTGATGTAAAGCCGATAGGTGAAGGGTTATCTGAATTAAGAATAA
CAGAAGGGAAAGGCTACCGTCTGTACTTGAAAAATCAGAATGGGGTGATTGTGATTTTGTTATGCGGTGGTGACAAATCC
ACACAGAAAGCGGATATTGAAAAGGCAAAATCTTTAGCAAAAGAGTTAGGAGTTTAG

Structures

Antitoxin

• AlphaFold DB: B9B0C2