Detailed information of TA system TA231871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 630272..631542
• Replicon: chromosome
• Accession: NZ_CP090778
• Organism: Burkholderia multivorans strain 2005Ycf971III

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Y92_RS05015
• Protein ID: WP_006410613.1
• Coordinates: 630272..630850 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9BS12
• Locus tag: L0Y92_RS05020
• Protein ID: WP_006406126.1
• Coordinates: 630985..631542 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y92_RS04995 (L0Y92_04995)	625560..626351	+	792	WP_035947285.1	enoyl-CoA hydratase	-
L0Y92_RS05000 (L0Y92_05000)	626348..627487	+	1140	WP_006410588.1	enoyl-CoA hydratase/isomerase family protein	-
L0Y92_RS05005 (L0Y92_05005)	627534..628454	-	921	WP_006406123.1	LysR family transcriptional regulator	-
L0Y92_RS05010 (L0Y92_05010)	628633..630171	+	1539	WP_006410596.1	MFS transporter	-
L0Y92_RS05015 (L0Y92_05015)	630272..630850	-	579	WP_006410613.1	HD domain-containing protein	Toxin
L0Y92_RS05020 (L0Y92_05020)	630985..631542	-	558	WP_006406126.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y92_RS05025 (L0Y92_05025)	632055..633458	+	1404	WP_006406128.1	hypothetical protein	-
L0Y92_RS05030 (L0Y92_05030)	633469..634089	-	621	WP_006410617.1	isochorismatase family cysteine hydrolase	-
L0Y92_RS05035 (L0Y92_05035)	634678..635121	-	444	WP_223852633.1	antibiotic biosynthesis monooxygenase	-
L0Y92_RS05040 (L0Y92_05040)	635221..636246	-	1026	WP_006406131.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21384.10 Da
• Isoelectric Point: 4.9434

>T231871 WP_006410613.1 NZ_CP090778:c630850-630272 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T231871 NZ_CP126977:c1261758-1261351 [Gallibacterium anatis]
ATGCTGAAATATATGTTGGATACCAATATCGTTATTTTTACGATAAAAAATAAGCCGCCACATTTGTTGCCGTTATTTAA
TGAAAATCAATCTATGCTTTGTATCAGCTCGATTACATTAATGGAGCTGGTTTATGGGGCAGAGAAAAGCAAAAAAACGG
CACAGAATCTTGCCGTTATTGAATCTTTCTGTGCAAGATTAGCCGTTTTGGATTATGACGAGGCAGCAGCATATCATAGT
GGGCAGATAAGAGCTGAATTAGCAAAAATTGGACAACCTATTGGATCATATGACGCAATGATCGCCGGGCACGCAAGGAG
TCTAGGCTTGACAGTTGTTACTAACAATATGAATGAGTTTTCACGGGTAGAGGGGTTAAGAGTAATTGATTGGAGTAAGC
CGATGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20378.30 Da
• Isoelectric Point: 7.8341

>AT231871 WP_006406126.1 NZ_CP090778:c631542-630985 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT231871 NZ_CP126977:c1261997-1261758 [Gallibacterium anatis]
ATGAGTGTAGTGACCGCAACTGTTTTTATGAATAATAAAAGCCAAGCTATCAGAATTCCGAAAGCTGCAGAATTACCTAA
TACTACAAAAAGTGTAAATATCATTATTCAAGGGGATATGCGTATTATCACACCTCTCAATAATGTTTGGGACAGCTGGT
TCAATGATTCAAATTCCGTATCGGACGATTTTATGTTAAGTCGTGAGCAACCACAGATGCAGGAAAGGGAAGAATTATAA

Structures

Antitoxin

• AlphaFold DB: B9BS12