231870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1724595..1725865 Replicon chromosome
Accession NZ_CP090776
Organism Burkholderia multivorans strain 2006Ycf877

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z45_RS27085 Protein ID WP_249475182.1
Coordinates 1725287..1725865 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z45_RS27080 Protein ID WP_249475180.1
Coordinates 1724595..1725152 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z45_RS27055 (L0Z45_27055) 1719890..1720915 + 1026 WP_249475178.1 aldo/keto reductase -
L0Z45_RS27060 (L0Z45_27060) 1721015..1721458 + 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Z45_RS27065 (L0Z45_27065) 1721632..1722009 - 378 WP_146124054.1 hypothetical protein -
L0Z45_RS27070 (L0Z45_27070) 1722047..1722667 + 621 WP_276520885.1 isochorismatase family cysteine hydrolase -
L0Z45_RS27075 (L0Z45_27075) 1722678..1724081 - 1404 WP_088929364.1 hypothetical protein -
L0Z45_RS27080 (L0Z45_27080) 1724595..1725152 + 558 WP_249475180.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z45_RS27085 (L0Z45_27085) 1725287..1725865 + 579 WP_249475182.1 HD domain-containing protein Toxin
L0Z45_RS27090 (L0Z45_27090) 1725966..1727504 - 1539 WP_249475185.1 MFS transporter -
L0Z45_RS27095 (L0Z45_27095) 1727683..1728603 + 921 WP_065496151.1 LysR family transcriptional regulator -
L0Z45_RS27100 (L0Z45_27100) 1728650..1729789 - 1140 WP_217057604.1 enoyl-CoA hydratase/isomerase family protein -
L0Z45_RS27105 (L0Z45_27105) 1729786..1730577 - 792 WP_249475187.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-163)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21424.13 Da        Isoelectric Point: 5.1007

>T231870 WP_249475182.1 NZ_CP090776:1725287-1725865 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALHGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Download         Length: 579 bp

>T231870 NZ_CP126977:c1208718-1208431 [Gallibacterium anatis]
ATGGCTTATGCAATTAAGGTGCATAGTGATTTTGTGGCAGAATTGAATAAATTAGATTCTACTATAAAAAATCAGCTACG
AAAGAAATTGGAAAAAGTAGTACACAATCCACATATTCCTAAAAATAGATTAAGTGGAGAGCTTCATAATTGTTATAAAA
TTAAACTAAGAAAAGCTGGAGTGCGGTTGGTTTACCAAGTCAATGATGATGAAATTTATATCTTATTACTGACAGTTGGT
AAGCGAGAGGCTAAGCAAGTTTATAACACTGCATTAAATCGAGTTTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20396.36 Da        Isoelectric Point: 8.5490

>AT231870 WP_249475180.1 NZ_CP090776:1724595-1725152 [Burkholderia multivorans]
MPNSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231870 NZ_CP126977:c1208976-1208728 [Gallibacterium anatis]
ATGGCTAATTTAAATATTCGTATTGATGATACTATTAAACAGCGGGCATTTTTAGCTTTTGATAATTTAGGCATTAATCC
ATCGGAAGCAATCCGTACATTTTTGACCTATGTCGCAGATACAGGGAGGATGCCAATTAAACAAATTATTGTCTCGGATG
AAGACGCTGAGCTTTATGAGGTAGTGAAAAAACGCTTAAATGAACCGGAGAAAATCACTGCAACTACATTGGATGAGCTT
TTCTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References