Detailed information of TA system TA231869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1564300..1564955
• Replicon: chromosome
• Accession: NZ_CP090776
• Organism: Burkholderia multivorans strain 2006Ycf877

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B9BGY2
• Locus tag: L0Z45_RS26415
• Protein ID: WP_006403072.1
• Coordinates: 1564300..1564719 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L0Z45_RS26420
• Protein ID: WP_065496259.1
• Coordinates: 1564716..1564955 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z45_RS26390 (L0Z45_26390)	1559639..1560433	+	795	WP_105848189.1	AraC family transcriptional regulator	-
L0Z45_RS26395 (L0Z45_26395)	1560689..1561639	+	951	WP_217078394.1	DMT family transporter	-
L0Z45_RS26400 (L0Z45_26400)	1561835..1562410	+	576	WP_053298362.1	hypothetical protein	-
L0Z45_RS26405 (L0Z45_26405)	1562504..1562638	-	135	WP_006409923.1	entericidin A/B family lipoprotein	-
L0Z45_RS26410 (L0Z45_26410)	1562871..1564166	+	1296	WP_035487510.1	aspartate carbamoyltransferase	-
L0Z45_RS26415 (L0Z45_26415)	1564300..1564719	-	420	WP_006403072.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z45_RS26420 (L0Z45_26420)	1564716..1564955	-	240	WP_065496259.1	Arc family DNA-binding protein	Antitoxin
L0Z45_RS26425 (L0Z45_26425)	1565260..1567506	+	2247	WP_006403070.1	TonB-dependent siderophore receptor	-
L0Z45_RS26430 (L0Z45_26430)	1567510..1568265	+	756	WP_006403069.1	tetratricopeptide repeat protein	-
L0Z45_RS26435 (L0Z45_26435)	1568262..1568945	+	684	WP_070554638.1	Fe2+-dependent dioxygenase	-
L0Z45_RS26440 (L0Z45_26440)	1568959..1569162	-	204	WP_006403067.1	hypothetical protein	-
L0Z45_RS26445 (L0Z45_26445)	1569751..1569894	+	144	WP_006409932.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15086.28 Da
• Isoelectric Point: 5.2157

>T231869 WP_006403072.1 NZ_CP090776:c1564719-1564300 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Nucleotide

• Length: 420 bp

>T231869 NZ_CP126977:685451-685795 [Gallibacterium anatis]
ATGAATACAGATAAATTGATTACCTTTATCGAAACGCCGATTTTTGAAGAAGATAGAAAAGCCTTGCTTTCTGACGAGGA
ATATCAGGCATTTCAAGCCTATATGTTAGATAACTTTCATTTAGGTGATTTTATTCAACATACCGGTGGTTGCCAAAAAA
TCAGGTGGAAATTATCAGGTAACAATAAAGGTAAAAGTGGCGGTGTAAGAATTATCTATTATTCGCTCACAGCCAAAGGA
AAGTTATATTTATTGATGATGTATCCAAAGAGTGAAAAAGATAATATGAATGCCGCAGAAAAAGCGATTTTAAAATCAAT
TGTTGATCAATTAAAAGGAGATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8750.96 Da
• Isoelectric Point: 5.1133

>AT231869 WP_065496259.1 NZ_CP090776:c1564955-1564716 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Nucleotide

• Length: 240 bp

>AT231869 NZ_CP126977:685798-686094 [Gallibacterium anatis]
ATGGATAAAAAATTATTTGATCGTCTAGTTAAAAGTGCTGAACAAATGGTTGCCATTGAAAAAGGTGAAATGCAGCCTGC
TCCTCATACTGTAACCACATTCCGCATTCCTGATGTGAAAAAAATCCGCGCCAACACGCATTTAAAGCAAAATGAATTTG
CAGATTTATTAGGCGTAAGTACTGCATTGGTACAATCTTGGGAAACGGCTCGCCGTGTGCCGAATGGTCCGGCGTTAAAA
TTGCTGAACATCATTGAGCAACAGCCGCAAATTATTGATACTTTAAGAGCAATTTAA

Structures

Toxin

• AlphaFold DB: B9BGY2