Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1365911..1367658 | Replicon | chromosome |
| Accession | NZ_CP090776 | ||
| Organism | Burkholderia multivorans strain 2006Ycf877 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | L0Z45_RS25395 | Protein ID | WP_065496359.1 |
| Coordinates | 1366762..1367658 (-) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Z45_RS25390 | Protein ID | WP_006396780.1 |
| Coordinates | 1365911..1366765 (-) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z45_RS25370 (L0Z45_25370) | 1361082..1362572 | - | 1491 | WP_088924112.1 | aldehyde dehydrogenase | - |
| L0Z45_RS25375 (L0Z45_25375) | 1362634..1363464 | - | 831 | WP_006403212.1 | aspartate dehydrogenase | - |
| L0Z45_RS25380 (L0Z45_25380) | 1363457..1365124 | - | 1668 | WP_012216808.1 | thiamine pyrophosphate-binding protein | - |
| L0Z45_RS25385 (L0Z45_25385) | 1365117..1365914 | - | 798 | WP_006396781.1 | SDR family oxidoreductase | - |
| L0Z45_RS25390 (L0Z45_25390) | 1365911..1366765 | - | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z45_RS25395 (L0Z45_25395) | 1366762..1367658 | - | 897 | WP_065496359.1 | alpha/beta fold hydrolase | Toxin |
| L0Z45_RS25400 (L0Z45_25400) | 1367677..1368204 | - | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Z45_RS25405 (L0Z45_25405) | 1368232..1369002 | - | 771 | WP_059940455.1 | SDR family oxidoreductase | - |
| L0Z45_RS25410 (L0Z45_25410) | 1368995..1370065 | - | 1071 | WP_006403208.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z45_RS25415 (L0Z45_25415) | 1370113..1370424 | - | 312 | WP_053298417.1 | hypothetical protein | - |
| L0Z45_RS25420 (L0Z45_25420) | 1370426..1370743 | - | 318 | WP_053298416.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z45_RS25425 (L0Z45_25425) | 1371180..1372259 | + | 1080 | WP_039217461.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30553.81 Da Isoelectric Point: 8.0534
>T231868 WP_065496359.1 NZ_CP090776:c1367658-1366762 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
Download Length: 897 bp
>T231868 NZ_CP126975:c2069634-2069251 [Gallibacterium anatis]
ATGAGAATATTTAAAACTAAAGCTTTTAACAAATTTGCTTTAAAAAATGGTATTCCTGACAGTGAATTAATCAATGCTAT
AACGAGGGTAGAGCAAGGATTAATAGATGCTGATTTAGGCGGTAATATTATTAAGCAGAGAATAGCCAGAAAAGGGCAGG
GACGTAGTGGTGGATTCCGTTCTTTTATTTTTTATTGTATCCAAAATAACAGCTATTTTGTTGCCGGAATTAGTAAAAAT
GACAGAGAAAATATTTCATCACAAGAGTTAGCAGCGTTAAAGGCATTGGCTAGAGAATATACTCGACTAACAGCAAAACA
GATTGAAGCACAGATCGAAAACGGATTATTCATCGAAATTTTACCGGAGGCAGAGGATGAGTGA
ATGAGAATATTTAAAACTAAAGCTTTTAACAAATTTGCTTTAAAAAATGGTATTCCTGACAGTGAATTAATCAATGCTAT
AACGAGGGTAGAGCAAGGATTAATAGATGCTGATTTAGGCGGTAATATTATTAAGCAGAGAATAGCCAGAAAAGGGCAGG
GACGTAGTGGTGGATTCCGTTCTTTTATTTTTTATTGTATCCAAAATAACAGCTATTTTGTTGCCGGAATTAGTAAAAAT
GACAGAGAAAATATTTCATCACAAGAGTTAGCAGCGTTAAAGGCATTGGCTAGAGAATATACTCGACTAACAGCAAAACA
GATTGAAGCACAGATCGAAAACGGATTATTCATCGAAATTTTACCGGAGGCAGAGGATGAGTGA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231868 WP_006396780.1 NZ_CP090776:c1366765-1365911 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231868 NZ_CP126975:c2069258-2068956 [Gallibacterium anatis]
ATGAGTGAATTGTTGGCAATGATCCACGAAAATGCGGCGGATTTACATAAAGCCGGCATTATTAATAAAAAAACAATGAA
AGAATTTGATCAGCTTTGTTTGACACCTGTTGTAACTTATACGCCGGACGAAATTAGAGCGATTCGTGAAAAAGAACAGG
TATCCCAAGCGGTATTCGCACATTATCTTAATGTGAGTAAAAATATGATTTCCGAATGGGAACGAGGCGTTAAAAAACCA
AGTGGTGCAGCATTAAAGTTGCTTAATTTGGTACAGCATAATGGTATTGAGATTCTTGTGTAG
ATGAGTGAATTGTTGGCAATGATCCACGAAAATGCGGCGGATTTACATAAAGCCGGCATTATTAATAAAAAAACAATGAA
AGAATTTGATCAGCTTTGTTTGACACCTGTTGTAACTTATACGCCGGACGAAATTAGAGCGATTCGTGAAAAAGAACAGG
TATCCCAAGCGGTATTCGCACATTATCTTAATGTGAGTAAAAATATGATTTCCGAATGGGAACGAGGCGTTAAAAAACCA
AGTGGTGCAGCATTAAAGTTGCTTAATTTGGTACAGCATAATGGTATTGAGATTCTTGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|