Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-PumB/upstrm_HI1419-dnstrm_HI1420 |
Location | 393447..394067 | Replicon | chromosome |
Accession | NZ_CP090776 | ||
Organism | Burkholderia multivorans strain 2006Ycf877 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3KJN2 |
Locus tag | L0Z45_RS21210 | Protein ID | WP_012217495.1 |
Coordinates | 393750..394067 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | B9B269 |
Locus tag | L0Z45_RS21205 | Protein ID | WP_006398012.1 |
Coordinates | 393447..393746 (-) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Z45_RS21180 (L0Z45_21180) | 388683..389954 | + | 1272 | WP_006404220.1 | anthranilate 1,2-dioxygenase large subunit AndAc | - |
L0Z45_RS21185 (L0Z45_21185) | 389969..390457 | + | 489 | WP_006398008.1 | anthranilate 1,2-dioxygenase small subunit AndAd | - |
L0Z45_RS21190 (L0Z45_21190) | 390475..390801 | + | 327 | WP_006404219.1 | anthranilate 1,2-dioxygenase ferredoxin subunit AndAb | - |
L0Z45_RS21195 (L0Z45_21195) | 390791..392011 | + | 1221 | WP_088929773.1 | anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase | - |
L0Z45_RS21200 (L0Z45_21200) | 392126..393412 | + | 1287 | WP_249475593.1 | DUF445 domain-containing protein | - |
L0Z45_RS21205 (L0Z45_21205) | 393447..393746 | - | 300 | WP_006398012.1 | putative addiction module antidote protein | Antitoxin |
L0Z45_RS21210 (L0Z45_21210) | 393750..394067 | - | 318 | WP_012217495.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L0Z45_RS21215 (L0Z45_21215) | 394432..396072 | + | 1641 | WP_006398015.1 | acetolactate synthase large subunit | - |
L0Z45_RS21220 (L0Z45_21220) | 396101..397534 | + | 1434 | WP_006404214.1 | aldehyde dehydrogenase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12110.94 Da Isoelectric Point: 10.2349
>T231866 WP_012217495.1 NZ_CP090776:c394067-393750 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE
Download Length: 318 bp
>T231866 NZ_CP126975:c1410549-1410262 [Gallibacterium anatis]
ATGGCTTATGCAATTAAGGTGCATAGTGATTTTGTGGCAGAATTGAATAAATTAGATTCTACTATAAAAAATCAGCTACG
AAAGAAATTGGAAAAAGTAGTACACAATCCACATATTCCTAAAAATAGATTAAGTGGAGAGCTTCATAATTGTTATAAAA
TTAAACTAAGAAAAGCTGGAGTGCGGTTGGTTTACCAAGTCAATGATGATGAAATTTATATCTTATTACTGACAGTTGGT
AAGCGAGAGGCTAAGCAAGTTTATAACACTGCATTAAATCGAGTTTAA
ATGGCTTATGCAATTAAGGTGCATAGTGATTTTGTGGCAGAATTGAATAAATTAGATTCTACTATAAAAAATCAGCTACG
AAAGAAATTGGAAAAAGTAGTACACAATCCACATATTCCTAAAAATAGATTAAGTGGAGAGCTTCATAATTGTTATAAAA
TTAAACTAAGAAAAGCTGGAGTGCGGTTGGTTTACCAAGTCAATGATGATGAAATTTATATCTTATTACTGACAGTTGGT
AAGCGAGAGGCTAAGCAAGTTTATAACACTGCATTAAATCGAGTTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10605.00 Da Isoelectric Point: 6.6381
>AT231866 WP_006398012.1 NZ_CP090776:c393746-393447 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA
Download Length: 300 bp
>AT231866 NZ_CP126975:c1410885-1410559 [Gallibacterium anatis]
TTGAAAAATCAGCAAAATCAAGCTGCGGTCATTGCATTTGTTTTACGTTTGTTTTACTATTATTCAAAAGGAGGGCTTAT
GGCTAATTTAAATATTCGTATTGATGATACTATTAAACAGAGGGCATTTTTAGCTTTTGATAATTTAGGCATTAATCCAT
CGGAAGCAATCCGTACATTTTTGACCTATGTCGCAGACACAGGGAGGATGCCAATTAAACAAATTATTGTCTCGGATGAA
GACACTGAGCTTTATGAGGTAGTGAAAAAACGCTTAAATGAACCGGAGAAAATCACTGCAACTACATTGGATGAGCTTTT
CTCTTAG
TTGAAAAATCAGCAAAATCAAGCTGCGGTCATTGCATTTGTTTTACGTTTGTTTTACTATTATTCAAAAGGAGGGCTTAT
GGCTAATTTAAATATTCGTATTGATGATACTATTAAACAGAGGGCATTTTTAGCTTTTGATAATTTAGGCATTAATCCAT
CGGAAGCAATCCGTACATTTTTGACCTATGTCGCAGACACAGGGAGGATGCCAATTAAACAAATTATTGTCTCGGATGAA
GACACTGAGCTTTATGAGGTAGTGAAAAAACGCTTAAATGAACCGGAGAAAATCACTGCAACTACATTGGATGAGCTTTT
CTCTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KJN2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KTI5 |