Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 393447..394067 Replicon chromosome
Accession NZ_CP090776
Organism Burkholderia multivorans strain 2006Ycf877

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z45_RS21210 Protein ID WP_012217495.1
Coordinates 393750..394067 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z45_RS21205 Protein ID WP_006398012.1
Coordinates 393447..393746 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z45_RS21180 (L0Z45_21180) 388683..389954 + 1272 WP_006404220.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Z45_RS21185 (L0Z45_21185) 389969..390457 + 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z45_RS21190 (L0Z45_21190) 390475..390801 + 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z45_RS21195 (L0Z45_21195) 390791..392011 + 1221 WP_088929773.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z45_RS21200 (L0Z45_21200) 392126..393412 + 1287 WP_249475593.1 DUF445 domain-containing protein -
L0Z45_RS21205 (L0Z45_21205) 393447..393746 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z45_RS21210 (L0Z45_21210) 393750..394067 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z45_RS21215 (L0Z45_21215) 394432..396072 + 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z45_RS21220 (L0Z45_21220) 396101..397534 + 1434 WP_006404214.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231866 WP_012217495.1 NZ_CP090776:c394067-393750 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231866 NZ_CP126975:c1410549-1410262 [Gallibacterium anatis]
ATGGCTTATGCAATTAAGGTGCATAGTGATTTTGTGGCAGAATTGAATAAATTAGATTCTACTATAAAAAATCAGCTACG
AAAGAAATTGGAAAAAGTAGTACACAATCCACATATTCCTAAAAATAGATTAAGTGGAGAGCTTCATAATTGTTATAAAA
TTAAACTAAGAAAAGCTGGAGTGCGGTTGGTTTACCAAGTCAATGATGATGAAATTTATATCTTATTACTGACAGTTGGT
AAGCGAGAGGCTAAGCAAGTTTATAACACTGCATTAAATCGAGTTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231866 WP_006398012.1 NZ_CP090776:c393746-393447 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231866 NZ_CP126975:c1410885-1410559 [Gallibacterium anatis]
TTGAAAAATCAGCAAAATCAAGCTGCGGTCATTGCATTTGTTTTACGTTTGTTTTACTATTATTCAAAAGGAGGGCTTAT
GGCTAATTTAAATATTCGTATTGATGATACTATTAAACAGAGGGCATTTTTAGCTTTTGATAATTTAGGCATTAATCCAT
CGGAAGCAATCCGTACATTTTTGACCTATGTCGCAGACACAGGGAGGATGCCAATTAAACAAATTATTGTCTCGGATGAA
GACACTGAGCTTTATGAGGTAGTGAAAAAACGCTTAAATGAACCGGAGAAAATCACTGCAACTACATTGGATGAGCTTTT
CTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References