Detailed information of TA system TA231865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3495901..3496538
• Replicon: chromosome
• Accession: NZ_CP090774
• Organism: Burkholderia multivorans strain 2006Ycf877

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z45_RS16700
• Protein ID: WP_105800840.1
• Coordinates: 3495901..3496302 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: L0Z45_RS16705
• Protein ID: WP_006408845.1
• Coordinates: 3496302..3496538 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z45_RS16690 (L0Z45_16690)	3493239..3494381	+	1143	WP_070555436.1	alginate lyase family protein	-
L0Z45_RS16695 (L0Z45_16695)	3494408..3495796	+	1389	WP_006408285.1	L-serine ammonia-lyase	-
L0Z45_RS16700 (L0Z45_16700)	3495901..3496302	-	402	WP_105800840.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z45_RS16705 (L0Z45_16705)	3496302..3496538	-	237	WP_006408845.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z45_RS16710 (L0Z45_16710)	3496726..3498429	+	1704	WP_249474124.1	thiamine pyrophosphate-binding protein	-
L0Z45_RS16715 (L0Z45_16715)	3498426..3499514	+	1089	WP_249474127.1	ADP-heptose--LPS heptosyltransferase	-
L0Z45_RS16720 (L0Z45_16720)	3499633..3500664	-	1032	WP_012212492.1	helix-turn-helix domain-containing protein	-
L0Z45_RS16725 (L0Z45_16725)	3500835..3501377	-	543	WP_070555506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15005.26 Da
• Isoelectric Point: 5.7429

>T231865 WP_105800840.1 NZ_CP090774:c3496302-3495901 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCANPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T231865 NZ_CP126975:705510-705854 [Gallibacterium anatis]
ATGAATACAGATAAATTTATTACCTTTATCGAAACGCCGATTTTTGAAGAAGATAGAAAAGCCTTGCTTTCTGACGAGGA
ATATCAGGCATTTCAAGCCTATATGTTAGATAACTTTCATTTAGGTGATTTTATTCAGCATACCGGTGGTTGCCAAAAGA
TCAGGTGGAAATTATCAGGTAACAATAAAGGTAAAAGTGGCGGTGTAAGAATTATCTATTACTCGCTCACAGCTAAAGGA
AAGTTATATTTATTGATGATGTATCCAAAGAGTGAAAAAGATAATATGAATGCCACAGAAAAAGCGATTTTAAAATCAAT
CGTTGATCAATTAAAAGGAGATTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT231865 WP_006408845.1 NZ_CP090774:c3496538-3496302 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT231865 NZ_CP126975:705857-706153 [Gallibacterium anatis]
ATGGATAAAAAATTATTTGATCGTTTAGTTAAAAGTGCTGAACAAATGGTTGCTATTGAAAAAGGTGAAATGCAATCTGC
TCCTCATACTGTAACCACATTCCGCATTCCTGATGTGAAAAAAATCCGCGCCAACACGCATTTAAAGCAAAATGAATTTG
CAGATTTATTAGGCGTAAGCACAGCATTAGTACAATCTTGGGAAACGGCTCGCCGTGTGCCGAACGGTCCGGCGTTAAAA
TTGCTGAACATCATTGAGCAACAGCCGCAAATTATTGATACTTTAAGAGCAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1