Detailed information of TA system TA231864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3401481..3402037
• Replicon: chromosome
• Accession: NZ_CP090774
• Organism: Burkholderia multivorans strain 2006Ycf877

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Z45_RS16245
• Protein ID: WP_229202334.1
• Coordinates: 3401786..3402037 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: L0Z45_RS16240
• Protein ID: WP_004541313.1
• Coordinates: 3401481..3401759 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z45_RS16220 (L0Z45_16220)	3398103..3398336	-	234	WP_249474042.1	hypothetical protein	-
L0Z45_RS16225 (L0Z45_16225)	3398569..3399570	+	1002	WP_249474045.1	replication protein RepA	-
L0Z45_RS16230 (L0Z45_16230)	3399968..3400348	-	381	WP_249474049.1	hypothetical protein	-
L0Z45_RS16235 (L0Z45_16235)	3400942..3401400	+	459	WP_249474053.1	hypothetical protein	-
L0Z45_RS16240 (L0Z45_16240)	3401481..3401759	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
L0Z45_RS16245 (L0Z45_16245)	3401786..3402037	+	252	WP_229202334.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z45_RS16250 (L0Z45_16250)	3402040..3402354	+	315	WP_249474058.1	hypothetical protein	-
L0Z45_RS29690	3402347..3402481	+	135	WP_011051575.1	hypothetical protein	-
L0Z45_RS16255 (L0Z45_16255)	3402613..3403580	+	968	WP_249474668.1	IS5 family transposase	-
L0Z45_RS16260 (L0Z45_16260)	3403800..3404941	+	1142	WP_249474670.1	IS3 family transposase	-
L0Z45_RS16265 (L0Z45_16265)	3405059..3405199	+	141	Protein_3187	transposase	-
L0Z45_RS16270 (L0Z45_16270)	3405326..3406060	+	735	WP_249474672.1	SDR family NAD(P)-dependent oxidoreductase	-
L0Z45_RS16275 (L0Z45_16275)	3406135..3406434	+	300	WP_249474061.1	hypothetical protein	-
L0Z45_RS16280 (L0Z45_16280)	3406741..3407025	+	285	Protein_3190	PDDEXK nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3394005..3417131	23126

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9594.91 Da
• Isoelectric Point: 9.9718

>T231864 WP_229202334.1 NZ_CP090774:3401786-3402037 [Burkholderia multivorans]
MQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231864 NZ_CP126975:574025-574159 [Gallibacterium anatis]
GTGAATAAAGGATATCGTATTTATCTGAAAAATCAGAATGGAGTTATTGTCATTTTATTATGTGGCGGTGATAAATCGAC
ACAGAAAGCGGATATTGAAAAGGCAAAATCTTTAGCAAAAGAGTTAGGAGTTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231864 WP_004541313.1 NZ_CP090774:3401481-3401759 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231864 NZ_CP126975:574161-574445 [Gallibacterium anatis]
ATGGTTGAGAAATTACACGATTTTGATATGTCCGAACATTTGCGTACAGAAGAAGAAATTCAGCTTTATCTTAATGAAAT
TTTGGCAGAAGGTGATGTTAATTTATTGCTTTCTGCATTGGGAGATATTGCAAAAGCGAGAAATATGAGTCAGATTGCTC
GAGAAGTTGGTGTGACAAGAGAGGGATTATATAAAGCACTATCCGGTCAAGGAAATCCAACATTTGCGACAGTATTTAAA
GTAATGCAGGCATTAAATTTAAATTTAGAAGTACGACACGCTTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0