Detailed information of TA system TA231863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1090163..1090863
• Replicon: chromosome
• Accession: NZ_CP090774
• Organism: Burkholderia multivorans strain 2006Ycf877

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z45_RS05135
• Protein ID: WP_217092519.1
• Coordinates: 1090486..1090863 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z45_RS05130
• Protein ID: WP_006405635.1
• Coordinates: 1090163..1090486 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z45_RS05110 (L0Z45_05110)	1085512..1086972	+	1461	WP_249474494.1	PLP-dependent aminotransferase family protein	-
L0Z45_RS05115 (L0Z45_05115)	1087131..1089029	+	1899	WP_249467178.1	molecular chaperone HtpG	-
L0Z45_RS05120 (L0Z45_05120)	1089038..1089652	+	615	WP_217045819.1	chorismate lyase	-
L0Z45_RS05125 (L0Z45_05125)	1089649..1090140	+	492	WP_053296985.1	DNA-deoxyinosine glycosylase	-
L0Z45_RS05130 (L0Z45_05130)	1090163..1090486	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z45_RS05135 (L0Z45_05135)	1090486..1090863	-	378	WP_217092519.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z45_RS05140 (L0Z45_05140)	1090848..1091216	+	369	WP_249474684.1	hypothetical protein	-
L0Z45_RS05145 (L0Z45_05145)	1091393..1091647	-	255	WP_059940739.1	hypothetical protein	-
L0Z45_RS05150 (L0Z45_05150)	1091876..1092793	+	918	WP_053296988.1	spermidine synthase	-
L0Z45_RS05155 (L0Z45_05155)	1092990..1093223	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z45_RS05160 (L0Z45_05160)	1093220..1094770	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z45_RS05165 (L0Z45_05165)	1094874..1095320	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13529.54 Da
• Isoelectric Point: 9.5723

>T231863 WP_217092519.1 NZ_CP090774:c1090863-1090486 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEHSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231863 NZ_CP126974:c5183549-5183166 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231863 WP_006405635.1 NZ_CP090774:c1090486-1090163 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231863 NZ_CP126974:c5183791-5183549 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: B9BQB8