Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 3493475..3494112 Replicon chromosome
Accession NZ_CP090771
Organism Burkholderia multivorans strain 2007Ycf278

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z11_RS16680 Protein ID WP_105800840.1
Coordinates 3493475..3493876 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132EWB1
Locus tag L0Z11_RS16685 Protein ID WP_006408845.1
Coordinates 3493876..3494112 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z11_RS16670 (L0Z11_16670) 3490813..3491955 + 1143 WP_070555436.1 alginate lyase family protein -
L0Z11_RS16675 (L0Z11_16675) 3491982..3493370 + 1389 WP_006408285.1 L-serine ammonia-lyase -
L0Z11_RS16680 (L0Z11_16680) 3493475..3493876 - 402 WP_105800840.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z11_RS16685 (L0Z11_16685) 3493876..3494112 - 237 WP_006408845.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z11_RS16690 (L0Z11_16690) 3494300..3496003 + 1704 WP_249474124.1 thiamine pyrophosphate-binding protein -
L0Z11_RS16695 (L0Z11_16695) 3496000..3497088 + 1089 WP_249474127.1 ADP-heptose--LPS heptosyltransferase -
L0Z11_RS16700 (L0Z11_16700) 3497207..3498238 - 1032 WP_012212492.1 helix-turn-helix domain-containing protein -
L0Z11_RS16705 (L0Z11_16705) 3498409..3498951 - 543 WP_070555506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15005.26 Da        Isoelectric Point: 5.7429

>T231857 WP_105800840.1 NZ_CP090771:c3493876-3493475 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCANPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Download         Length: 402 bp

>T231857 NZ_CP126974:1876419-1876521 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8915.00 Da        Isoelectric Point: 5.8651

>AT231857 WP_006408845.1 NZ_CP090771:c3494112-3493876 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp

>AT231857 NZ_CP126974:c1876528-1876383 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A132EWB1

References