Detailed information of TA system TA231856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3399061..3399617
• Replicon: chromosome
• Accession: NZ_CP090771
• Organism: Burkholderia multivorans strain 2007Ycf278

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Z11_RS16225
• Protein ID: WP_229202334.1
• Coordinates: 3399366..3399617 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: L0Z11_RS16220
• Protein ID: WP_004541313.1
• Coordinates: 3399061..3399339 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z11_RS16200 (L0Z11_16200)	3395683..3395916	-	234	WP_249474042.1	hypothetical protein	-
L0Z11_RS16205 (L0Z11_16205)	3396149..3397150	+	1002	WP_249474045.1	replication protein RepA	-
L0Z11_RS16210 (L0Z11_16210)	3397548..3397928	-	381	WP_249474049.1	hypothetical protein	-
L0Z11_RS16215 (L0Z11_16215)	3398522..3398980	+	459	WP_249474053.1	hypothetical protein	-
L0Z11_RS16220 (L0Z11_16220)	3399061..3399339	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
L0Z11_RS16225 (L0Z11_16225)	3399366..3399617	+	252	WP_229202334.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z11_RS16230 (L0Z11_16230)	3399620..3399934	+	315	WP_249474058.1	hypothetical protein	-
L0Z11_RS29695	3399927..3400061	+	135	WP_011051575.1	hypothetical protein	-
L0Z11_RS16235 (L0Z11_16235)	3400193..3401160	+	968	WP_249474668.1	IS5 family transposase	-
L0Z11_RS16240 (L0Z11_16240)	3401380..3402521	+	1142	WP_249474670.1	IS3 family transposase	-
L0Z11_RS16245 (L0Z11_16245)	3402639..3402827	+	189	Protein_3183	transposase	-
L0Z11_RS16250 (L0Z11_16250)	3402906..3403640	+	735	WP_249474672.1	SDR family NAD(P)-dependent oxidoreductase	-
L0Z11_RS16255 (L0Z11_16255)	3403715..3404014	+	300	WP_249474061.1	hypothetical protein	-
L0Z11_RS16260 (L0Z11_16260)	3404321..3404605	+	285	Protein_3186	PDDEXK nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3391585..3414711	23126

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9594.91 Da
• Isoelectric Point: 9.9718

>T231856 WP_229202334.1 NZ_CP090771:3399366-3399617 [Burkholderia multivorans]
MQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231856 NZ_CP126974:775059-775469 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231856 WP_004541313.1 NZ_CP090771:3399061-3399339 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231856 NZ_CP126974:774812-775078 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0