Detailed information of TA system TA231855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1087714..1088414
• Replicon: chromosome
• Accession: NZ_CP090771
• Organism: Burkholderia multivorans strain 2007Ycf278

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z11_RS05115
• Protein ID: WP_217092519.1
• Coordinates: 1088037..1088414 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z11_RS05110
• Protein ID: WP_006405635.1
• Coordinates: 1087714..1088037 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z11_RS05090 (L0Z11_05090)	1083063..1084523	+	1461	WP_249474494.1	PLP-dependent aminotransferase family protein	-
L0Z11_RS05095 (L0Z11_05095)	1084682..1086580	+	1899	WP_249467178.1	molecular chaperone HtpG	-
L0Z11_RS05100 (L0Z11_05100)	1086589..1087203	+	615	WP_217045819.1	chorismate lyase	-
L0Z11_RS05105 (L0Z11_05105)	1087200..1087691	+	492	WP_053296985.1	DNA-deoxyinosine glycosylase	-
L0Z11_RS05110 (L0Z11_05110)	1087714..1088037	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z11_RS05115 (L0Z11_05115)	1088037..1088414	-	378	WP_217092519.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z11_RS05120 (L0Z11_05120)	1088399..1088767	+	369	WP_249474684.1	hypothetical protein	-
L0Z11_RS05125 (L0Z11_05125)	1088944..1089198	-	255	WP_059940739.1	hypothetical protein	-
L0Z11_RS05130 (L0Z11_05130)	1089427..1090344	+	918	WP_053296988.1	spermidine synthase	-
L0Z11_RS05135 (L0Z11_05135)	1090541..1090774	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z11_RS05140 (L0Z11_05140)	1090771..1092321	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z11_RS05145 (L0Z11_05145)	1092425..1092871	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13529.54 Da
• Isoelectric Point: 9.5723

>T231855 WP_217092519.1 NZ_CP090771:c1088414-1088037 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEHSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231855 NZ_CP126974:347793-348140 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231855 WP_006405635.1 NZ_CP090771:c1088037-1087714 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231855 NZ_CP126974:348140-348439 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: B9BQB8