Detailed information of TA system TA231853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 918782..919482
• Replicon: chromosome
• Accession: NZ_CP090770
• Organism: Burkholderia multivorans strain 2007Ycf875II

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z18_RS16875
• Protein ID: WP_105801035.1
• Coordinates: 919105..919482 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z18_RS16870
• Protein ID: WP_006405635.1
• Coordinates: 918782..919105 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z18_RS16850 (L0Z18_16850)	914131..915591	+	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-
L0Z18_RS16855 (L0Z18_16855)	915750..917648	+	1899	WP_059875776.1	molecular chaperone HtpG	-
L0Z18_RS16860 (L0Z18_16860)	917657..918271	+	615	WP_249463432.1	chorismate lyase	-
L0Z18_RS16865 (L0Z18_16865)	918268..918759	+	492	WP_249463437.1	DNA-deoxyinosine glycosylase	-
L0Z18_RS16870 (L0Z18_16870)	918782..919105	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z18_RS16875 (L0Z18_16875)	919105..919482	-	378	WP_105801035.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z18_RS16880 (L0Z18_16880)	919467..919835	+	369	WP_249463891.1	hypothetical protein	-
L0Z18_RS16885 (L0Z18_16885)	920012..920266	-	255	WP_059940739.1	hypothetical protein	-
L0Z18_RS16890 (L0Z18_16890)	920494..921411	+	918	WP_088930384.1	spermidine synthase	-
L0Z18_RS16895 (L0Z18_16895)	921608..921841	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z18_RS16900 (L0Z18_16900)	921838..923388	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z18_RS16905 (L0Z18_16905)	923492..923938	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13598.65 Da
• Isoelectric Point: 9.7722

>T231853 WP_105801035.1 NZ_CP090770:c919482-919105 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231853 NZ_CP126974:194640-195125 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231853 WP_006405635.1 NZ_CP090770:c919105-918782 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231853 NZ_CP126974:194386-194652 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: B9BQB8