Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2452555..2453175 Replicon chromosome
Accession NZ_CP090769
Organism Burkholderia multivorans strain 2007Ycf875II

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z18_RS10605 Protein ID WP_012217495.1
Coordinates 2452555..2452872 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z18_RS10610 Protein ID WP_006398012.1
Coordinates 2452876..2453175 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z18_RS10595 (L0Z18_10595) 2449088..2450521 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Z18_RS10600 (L0Z18_10600) 2450550..2452190 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z18_RS10605 (L0Z18_10605) 2452555..2452872 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z18_RS10610 (L0Z18_10610) 2452876..2453175 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z18_RS10615 (L0Z18_10615) 2453210..2454496 - 1287 WP_249461891.1 DUF445 domain-containing protein -
L0Z18_RS10620 (L0Z18_10620) 2454611..2455831 - 1221 WP_249461894.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z18_RS10625 (L0Z18_10625) 2455821..2456147 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z18_RS10630 (L0Z18_10630) 2456165..2456653 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z18_RS10635 (L0Z18_10635) 2456668..2457939 - 1272 WP_249461897.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231852 WP_012217495.1 NZ_CP090769:2452555-2452872 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231852 NZ_CP126970:c1733911-1733654 [Corynebacterium sp. LM112]
ATGAGAACAATGAGTTACACGGAGTCGCGAGCCAACTACGCGAAAGTGCTCGATTCCGTCACCGATGATCGCGAGGCGGT
GGTGATCACCCGCGCCGGCCACGAGCCAGTGGTCATGGTGTCGCTCGCCGACTATGAATCACTCCGCGAGACCGCATACC
TCATGCGCTCCCCCGCCAATGCCCGACGCCTGTTCGACGCCATGGAACGGCTGGAGGGTGGACGCGGCGACGCCCACGAC
GTGATCGAGACCAACTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231852 WP_006398012.1 NZ_CP090769:2452876-2453175 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231852 NZ_CP126970:c1733649-1733392 [Corynebacterium sp. LM112]
ATGCTCCTCGTGTGGGATGAAAACGCCTGGGCCGATTACCTCTGGTGGCAGGCCCAGGACAGAAAGACCCTGAAGCGCAT
CAATCTGCTCCTCAAGGACATCGTCCGGAACGGCAATGAGGGTATCGGGAAGCCCGAGCCTCTCAAGCATGACTTCGCCG
GATACTGGTTGCGCCGGATCACCGACGAGCATCGGCTCGTCTACAAACACACGGAGACAGAGGTCCGGATCGCCGCGTGC
CGGTATCACTATGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References