Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 918918..920665 | Replicon | chromosome |
| Accession | NZ_CP090769 | ||
| Organism | Burkholderia multivorans strain 2007Ycf875II | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B9BHC0 |
| Locus tag | L0Z18_RS03925 | Protein ID | WP_006403210.1 |
| Coordinates | 918918..919814 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Z18_RS03930 | Protein ID | WP_006396780.1 |
| Coordinates | 919811..920665 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z18_RS03895 (L0Z18_03895) | 914317..915396 | - | 1080 | WP_249462492.1 | porin | - |
| L0Z18_RS03900 (L0Z18_03900) | 915833..916150 | + | 318 | WP_053298416.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z18_RS03905 (L0Z18_03905) | 916152..916463 | + | 312 | WP_053298417.1 | hypothetical protein | - |
| L0Z18_RS03910 (L0Z18_03910) | 916511..917581 | + | 1071 | WP_006413805.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z18_RS03915 (L0Z18_03915) | 917574..918344 | + | 771 | WP_006413827.1 | SDR family oxidoreductase | - |
| L0Z18_RS03920 (L0Z18_03920) | 918372..918899 | + | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Z18_RS03925 (L0Z18_03925) | 918918..919814 | + | 897 | WP_006403210.1 | alpha/beta fold hydrolase | Toxin |
| L0Z18_RS03930 (L0Z18_03930) | 919811..920665 | + | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z18_RS03935 (L0Z18_03935) | 920662..921459 | + | 798 | WP_006396781.1 | SDR family oxidoreductase | - |
| L0Z18_RS03940 (L0Z18_03940) | 921452..923119 | + | 1668 | WP_053298420.1 | thiamine pyrophosphate-binding protein | - |
| L0Z18_RS03945 (L0Z18_03945) | 923112..923942 | + | 831 | WP_006403212.1 | aspartate dehydrogenase | - |
| L0Z18_RS03950 (L0Z18_03950) | 924004..925494 | + | 1491 | WP_006403213.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30544.80 Da Isoelectric Point: 8.0446
>T231850 WP_006403210.1 NZ_CP090769:918918-919814 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
Download Length: 897 bp
>T231850 NZ_CP126970:1729963-1730244 [Corynebacterium sp. LM112]
GTGATCGTCTCTTTCGCCGACCGCGACGCTGAACGTCTGTTCTTGAGAAAGCGTGTCAGACGTCTCGACCCGCGCGTGCA
CAGGAAGGCGCTCATGAAGCTGTTGCTGCTCGATGCCGTCCACGAGCTCGGCGAGCTCCGCATTCCACCGGGCAATCGTC
TGGAAGCGCTCAAGGGCGACCGGATTGGTCAGCACAGCATCCGAATCAACGACCAGTGGCGGATCTGCTTCGTCTGGACT
GTCGCGGGTCCGAGCGAAGTTGAGATCGTCGACTATCACTAG
GTGATCGTCTCTTTCGCCGACCGCGACGCTGAACGTCTGTTCTTGAGAAAGCGTGTCAGACGTCTCGACCCGCGCGTGCA
CAGGAAGGCGCTCATGAAGCTGTTGCTGCTCGATGCCGTCCACGAGCTCGGCGAGCTCCGCATTCCACCGGGCAATCGTC
TGGAAGCGCTCAAGGGCGACCGGATTGGTCAGCACAGCATCCGAATCAACGACCAGTGGCGGATCTGCTTCGTCTGGACT
GTCGCGGGTCCGAGCGAAGTTGAGATCGTCGACTATCACTAG
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231850 WP_006396780.1 NZ_CP090769:919811-920665 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231850 NZ_CP126970:1730255-1730551 [Corynebacterium sp. LM112]
ATGGACGACAAGATTCCCCCGATCCATCCGGGTGAGATCCTCATGGAGGAGTTCCTCGGACCGATGGGCGTGACTCAGCA
TCGGTTGGCAGTGTCCATCGGTGTCCCGCCGCGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGGATCACGGCTGATA
CGGCTCTGCGTCTGGGACGCTACTTCGGCATGAGCGCGCAGTTCTGGATCAACCTCCAGTCTCATTACGACCTTGAGGTC
GAGAGGGACGCGCTTGGCGACACTCTCGATGACATCGAGCCGCTGCAGTCCGCGTGA
ATGGACGACAAGATTCCCCCGATCCATCCGGGTGAGATCCTCATGGAGGAGTTCCTCGGACCGATGGGCGTGACTCAGCA
TCGGTTGGCAGTGTCCATCGGTGTCCCGCCGCGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGGATCACGGCTGATA
CGGCTCTGCGTCTGGGACGCTACTTCGGCATGAGCGCGCAGTTCTGGATCAACCTCCAGTCTCATTACGACCTTGAGGTC
GAGAGGGACGCGCTTGGCGACACTCTCGATGACATCGAGCCGCTGCAGTCCGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|