Detailed information of TA system TA231849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 769319..769974
• Replicon: chromosome
• Accession: NZ_CP090769
• Organism: Burkholderia multivorans strain 2007Ycf875II

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z18_RS03210
• Protein ID: WP_006409935.1
• Coordinates: 769555..769974 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L0Z18_RS03205
• Protein ID: WP_249462451.1
• Coordinates: 769319..769558 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z18_RS03180 (L0Z18_03180)	764380..764523	-	144	WP_006409932.1	hypothetical protein	-
L0Z18_RS03185 (L0Z18_03185)	765112..765315	+	204	WP_006403067.1	hypothetical protein	-
L0Z18_RS03190 (L0Z18_03190)	765342..766013	-	672	Protein_630	Fe2+-dependent dioxygenase	-
L0Z18_RS03195 (L0Z18_03195)	766010..766765	-	756	WP_006403069.1	tetratricopeptide repeat protein	-
L0Z18_RS03200 (L0Z18_03200)	766769..769015	-	2247	WP_006403070.1	TonB-dependent siderophore receptor	-
L0Z18_RS03205 (L0Z18_03205)	769319..769558	+	240	WP_249462451.1	Arc family DNA-binding protein	Antitoxin
L0Z18_RS03210 (L0Z18_03210)	769555..769974	+	420	WP_006409935.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z18_RS03215 (L0Z18_03215)	770108..771403	-	1296	WP_249462452.1	aspartate carbamoyltransferase	-
L0Z18_RS03220 (L0Z18_03220)	771636..771770	+	135	WP_006409923.1	entericidin A/B family lipoprotein	-
L0Z18_RS03225 (L0Z18_03225)	771864..772439	-	576	WP_053298362.1	hypothetical protein	-
L0Z18_RS03230 (L0Z18_03230)	772635..773585	-	951	WP_217057526.1	DMT family transporter	-
L0Z18_RS03235 (L0Z18_03235)	773831..774625	-	795	WP_105777245.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15146.38 Da
• Isoelectric Point: 5.2157

>T231849 WP_006409935.1 NZ_CP090769:769555-769974 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Nucleotide

• Length: 420 bp

>T231849 NZ_CP126970:359094-359549 [Corynebacterium sp. LM112]
GTGAGTGGTTTCACCGTTATCTACGACGCCAACGTCCTATACCCCACTATGTTGCGCGACATCCTGATCCGACTGGCAGG
CACGGGCATTTACCAAGCCCGGTGGACCGAAGACATCTTGGATGAGGTCTTTCGCAACCTCCAGGCCAACCGGTCAGATC
TTGACCCCAGTAAACTACGCCGAACCAGAGAGCTGATGTGTCGGGCTGTGGATGACTGCCTGGTGACTGGGTATGAAGAT
TTAATTGAGTCATTGTCTCTACCGGATCCTGATGACCGTCATGTTCTTGCTGCTGCCATCAGATGTGGTGCCCAGGTGAT
CGTCACCGAAAACGCGCGGGATTTTCCTCAAGACGTGATGGATAGATACGGCATCGAGATCCAGGGTGCTGATGAGTTTT
TATGCGATCAGATTGATCTGTTTGGCACTCGTGTCCACCAGGCTGTTACCTACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8788.06 Da
• Isoelectric Point: 5.7066

>AT231849 WP_249462451.1 NZ_CP090769:769319-769558 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSIEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Nucleotide

• Length: 240 bp

>AT231849 NZ_CP126970:358648-359097 [Corynebacterium sp. LM112]
ATGTCACACCTACAGGACAATGAGCTCGCTAGCACGGCGGCCACAGCCCGCGAGGCTTTGCAGAAAATCAACCGCGTCCT
AAGCGATACATCTACCAACAAAGACGTGAAGGTCGTGGTGGAGAACTCTGATGACGTTATTCTTCTACCCAGAGAAGTCG
CCACCGTCCTCCGGGAGATCTTGGTTAATTCAGCAGCCGGCAGATCAGTAGGCGTAATCCCTATGCGGGCCGAGCTGACC
ACCCAGCAAGCAGCTAACCTGCTTAATGTCTCTCGTCCGCATGTCATTAAATTGATGGATGACGGTATCTTGCCAGGACA
TAAGGTTGGTACGCATCGACGCATCTATGCGGCCGACGTGCAGGCCTACAAACACCAACGAGATATCGATACCCGCACAG
CTGCAGATGATCTCACTGCCCTGACCGAGGAGATGGGGCTCTACGAGTGA