231848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 608385..609655 Replicon chromosome
Accession NZ_CP090769
Organism Burkholderia multivorans strain 2007Ycf875II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z18_RS02540 Protein ID WP_105774903.1
Coordinates 608385..608963 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z18_RS02545 Protein ID WP_217085942.1
Coordinates 609098..609655 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z18_RS02520 (L0Z18_02520) 603673..604464 + 792 WP_065496148.1 enoyl-CoA hydratase -
L0Z18_RS02525 (L0Z18_02525) 604461..605600 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Z18_RS02530 (L0Z18_02530) 605647..606567 - 921 WP_065496151.1 LysR family transcriptional regulator -
L0Z18_RS02535 (L0Z18_02535) 606746..608284 + 1539 WP_249462417.1 MFS transporter -
L0Z18_RS02540 (L0Z18_02540) 608385..608963 - 579 WP_105774903.1 HD domain-containing protein Toxin
L0Z18_RS02545 (L0Z18_02545) 609098..609655 - 558 WP_217085942.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z18_RS02550 (L0Z18_02550) 610168..611571 + 1404 WP_088929364.1 hypothetical protein -
L0Z18_RS02555 (L0Z18_02555) 611582..612202 - 621 WP_006410617.1 isochorismatase family cysteine hydrolase -
L0Z18_RS02560 (L0Z18_02560) 612793..613236 - 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Z18_RS02565 (L0Z18_02565) 613336..614361 - 1026 WP_006406131.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21461.19 Da        Isoelectric Point: 5.2986

>T231848 WP_105774903.1 NZ_CP090769:c608963-608385 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALHGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDVAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAHT

Download         Length: 579 bp

>T231848 NZ_CP126969:1434053-1434307 [Corynebacterium sp. R4]
GTGGTTCTGTCGTGGTCAACACATGGTTGGGTGGACTACCTGTACTGGCAGTCCACCGACAAGAAAGTGCTCAAGCGGAT
CAACACCCTAATCAAAGACATTCCACGCAACGGCCACGAAGGCATTGGTAAGCCGGAGCCACTCAAACACGAGTTCTCAG
GCTATTGGTCACGACGAATCACCGACGAACACCGCCTCGTCTACTCCTACGCTGAGGATTCCATTGTGATCCTCAGCTGC
AGGTACCACTACTAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20304.26 Da        Isoelectric Point: 8.1964

>AT231848 WP_217085942.1 NZ_CP090769:c609655-609098 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSGGAAARLVETL

Download         Length: 558 bp

>AT231848 NZ_CP126969:1433792-1434046 [Corynebacterium sp. R4]
ATGAAGACCATCTCGTACACCGAATCACGGAAACGGTACGCCGAAGTACTGGATCACGTCACCGACAACCGCGAACCCGT
TATCGTCACCCGCGCGGGTCACGAATCGGTTGTTGTGATGGCTCTCGACGATTTCAATTCCATGCAGGAAACGGCGTATC
TCATGCGCTCCCCTCGCAATGCACAGCGACTCTTTGAATCCCTCGAGGAAGTCCGCTCCGGAAAGACCACCCCGCACGAT
CTCATCGAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References