Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 50430..51076 Replicon plasmid p1_2008Ycf542
Accession NZ_CP090768
Organism Burkholderia multivorans strain 2008Ycf542

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y85_RS30125 Protein ID WP_012211060.1
Coordinates 50430..50837 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y85_RS30130 Protein ID WP_009692911.1
Coordinates 50834..51076 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y85_RS30090 (L0Y85_30090) 46714..47445 - 732 WP_009692920.1 hypothetical protein -
L0Y85_RS30095 (L0Y85_30095) 47442..47750 - 309 WP_009692919.1 hypothetical protein -
L0Y85_RS30100 (L0Y85_30100) 47761..47946 - 186 WP_009692918.1 hypothetical protein -
L0Y85_RS30105 (L0Y85_30105) 48058..48978 - 921 WP_009692917.1 serine protease -
L0Y85_RS30110 (L0Y85_30110) 48971..49129 - 159 WP_009692916.1 hypothetical protein -
L0Y85_RS30115 (L0Y85_30115) 49126..49734 - 609 WP_012211062.1 hypothetical protein -
L0Y85_RS30120 (L0Y85_30120) 49766..50086 - 321 WP_012211061.1 hypothetical protein -
L0Y85_RS30125 (L0Y85_30125) 50430..50837 - 408 WP_012211060.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y85_RS30130 (L0Y85_30130) 50834..51076 - 243 WP_009692911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Y85_RS30135 (L0Y85_30135) 51178..52146 - 969 WP_231856867.1 non-homologous end-joining DNA ligase -
L0Y85_RS30140 (L0Y85_30140) 52703..53374 + 672 WP_012211058.1 AAA family ATPase -
L0Y85_RS30145 (L0Y85_30145) 53374..54339 + 966 WP_012211057.1 ParB/RepB/Spo0J family partition protein -
L0Y85_RS30150 (L0Y85_30150) 55084..55941 + 858 WP_012211056.1 plasmid replication initiator TrfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..156151 156151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14613.77 Da        Isoelectric Point: 5.1402

>T231847 WP_012211060.1 NZ_CP090768:c50837-50430 [Burkholderia multivorans]
MSLYLLDTNILSNVIRDPRGACASRIGETRPEQVCTSIVVAAELRYGVCKRGSSALAQRVEQLLASLTVLPLQSDADQCY
GRLRADLERQGQLIGANDMLIAAHAMAVDAVLVTDNTAEFTRVTGLAVENWLRPA

Download         Length: 408 bp

>T231847 NZ_CP126969:1433792-1434046 [Corynebacterium sp. R4]
ATGAAGACCATCTCGTACACCGAATCACGGAAACGGTACGCCGAAGTACTGGATCACGTCACCGACAACCGCGAACCCGT
TATCGTCACCCGCGCGGGTCACGAATCGGTTGTTGTGATGGCTCTCGACGATTTCAATTCCATGCAGGAAACGGCGTATC
TCATGCGCTCCCCTCGCAATGCACAGCGACTCTTTGAATCCCTCGAGGAAGTCCGCTCCGGAAAGACCACCCCGCACGAT
CTCATCGAGGATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9309.54 Da        Isoelectric Point: 4.8615

>AT231847 WP_009692911.1 NZ_CP090768:c51076-50834 [Burkholderia multivorans]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAPSLRELFAQWAPLDETFPDIENLPAEPVDIE

Download         Length: 243 bp

>AT231847 NZ_CP126969:1434053-1434307 [Corynebacterium sp. R4]
GTGGTTCTGTCGTGGTCAACACATGGTTGGGTGGACTACCTGTACTGGCAGTCCACCGACAAGAAAGTGCTCAAGCGGAT
CAACACCCTAATCAAAGACATTCCACGCAACGGCCACGAAGGCATTGGTAAGCCGGAGCCACTCAAACACGAGTTCTCAG
GCTATTGGTCACGACGAATCACCGACGAACACCGCCTCGTCTACTCCTACGCTGAGGATTCCATTGTGATCCTCAGCTGC
AGGTACCACTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References