Detailed information of TA system TA231843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1218082..1218616
• Replicon: chromosome
• Accession: NZ_CP090765
• Organism: Burkholderia multivorans strain 2008Ycf542

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1W0YQN7
• Locus tag: L0Y85_RS05155
• Protein ID: WP_035954873.1
• Coordinates: 1218082..1218381 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: L0Y85_RS05160
• Protein ID: WP_105836542.1
• Coordinates: 1218371..1218616 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y85_RS05140 (L0Y85_05140)	1214432..1215739	+	1308	WP_039218025.1	shikimate transporter	-
L0Y85_RS05145 (L0Y85_05145)	1215774..1216391	-	618	WP_006397056.1	HNH endonuclease	-
L0Y85_RS05150 (L0Y85_05150)	1216673..1217974	+	1302	WP_006413706.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Y85_RS05155 (L0Y85_05155)	1218082..1218381	-	300	WP_035954873.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y85_RS05160 (L0Y85_05160)	1218371..1218616	-	246	WP_105836542.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Y85_RS05165 (L0Y85_05165)	1218756..1219526	+	771	WP_249458891.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Y85_RS05170 (L0Y85_05170)	1219589..1221889	-	2301	WP_175848076.1	ATP-dependent DNA helicase	-
L0Y85_RS05175 (L0Y85_05175)	1221886..1223589	-	1704	WP_105836543.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11570.09 Da
• Isoelectric Point: 7.3154

>T231843 WP_035954873.1 NZ_CP090765:c1218381-1218082 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231843 NZ_CP126964:1709035-1709301 [Pseudoglutamicibacter albus]
GTGACTAACTGGCGCCTGGTTTACTCGAAGCAGGCTCAGAAAGACGCAAAGAAACTGGCGTCGTCGGGGCTAAAGTCTAA
AGCACGAATGTTGTTGGACTTGCTCTCCGAAGACCCAATCACCAGTCCGCTCCGTTTCGAAAAACTTGTCGGAGACTTAG
CGGGTTGTTACTCGCGGCGGATTAACATTCAACATCGCCTCGTTTATGAGGTCGATGCCGAGGCTCGCGTCGTCCACGTT
TTACGGATGTGGACTCACTACGAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8648.71 Da
• Isoelectric Point: 6.4592

>AT231843 WP_105836542.1 NZ_CP090765:c1218616-1218371 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGDASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231843 NZ_CP126964:1708796-1709038 [Pseudoglutamicibacter albus]
ATGACTGCTGTAAACGCAACATCTGCACGCAATAATCTGTACCGTTTAATCGACCAAGTGAATGACGAGTCTGAGCCGGT
GACCATTACAGGGCAACGCGGCAACGCGGTCTTGGTAGGTGAGGAAGACTGGCGTGCTATCCAGGAAACACTGTTTCTGG
CATCGATCCCAGGAATGACTGAGTCCATCCTTGCCGCTCGAGCTGAAGGGATCGAGTCGGGCTCGGAGGAGCTTGACTGG
TGA

Structures

Toxin

• AlphaFold DB: A0A1W0YQN7