Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 906953..908700 | Replicon | chromosome |
| Accession | NZ_CP090765 | ||
| Organism | Burkholderia multivorans strain 2008Ycf542 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | L0Y85_RS03905 | Protein ID | WP_105836409.1 |
| Coordinates | 906953..907849 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Y85_RS03910 | Protein ID | WP_006396780.1 |
| Coordinates | 907846..908700 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y85_RS03875 (L0Y85_03875) | 902353..903432 | - | 1080 | WP_039217461.1 | porin | - |
| L0Y85_RS03880 (L0Y85_03880) | 903868..904185 | + | 318 | WP_006396774.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Y85_RS03885 (L0Y85_03885) | 904187..904498 | + | 312 | WP_006396775.1 | hypothetical protein | - |
| L0Y85_RS03890 (L0Y85_03890) | 904546..905616 | + | 1071 | WP_175848021.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Y85_RS03895 (L0Y85_03895) | 905609..906379 | + | 771 | WP_006413827.1 | SDR family oxidoreductase | - |
| L0Y85_RS03900 (L0Y85_03900) | 906407..906934 | + | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Y85_RS03905 (L0Y85_03905) | 906953..907849 | + | 897 | WP_105836409.1 | alpha/beta fold hydrolase | Toxin |
| L0Y85_RS03910 (L0Y85_03910) | 907846..908700 | + | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Y85_RS03915 (L0Y85_03915) | 908697..909494 | + | 798 | WP_006396781.1 | SDR family oxidoreductase | - |
| L0Y85_RS03920 (L0Y85_03920) | 909487..911154 | + | 1668 | WP_249458835.1 | thiamine pyrophosphate-binding protein | - |
| L0Y85_RS03925 (L0Y85_03925) | 911147..911977 | + | 831 | WP_105836412.1 | aspartate dehydrogenase | - |
| L0Y85_RS03930 (L0Y85_03930) | 912035..913525 | + | 1491 | WP_043278809.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30543.77 Da Isoelectric Point: 8.0534
>T231841 WP_105836409.1 NZ_CP090765:906953-907849 [Burkholderia multivorans]
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA
Download Length: 897 bp
>T231841 NZ_CP126962:c1168928-1168584 [Globicatella sanguinis]
ATGTTAGAAGTAAATAGCTATGTTCCATCAAAAGGAGATATCGTGTGGTTCGATTTTGATCCTTCAGCAGGAAAAGAAAT
TCAAAAAAGAAGACCAGCATTAGTCGTATCAAGACATGATTTTAATCGAACGACAGGATTTGCTATTGTGTGTCCAATTA
CAACAACACAGCTTAATTATCCAACAAGGGTTCAATTGCCCCATATGATAAAAACAAAGGGTCAAATTGTTATTCCACAA
TTAAAATCGTTGGACTTCAATAGTAGACAAGTAGAATTCATTGAAAAGTTGCCTGAAGGGTATATTCAAAGAGTCGATCA
AATTATTCAATATATTTTTAATTAG
ATGTTAGAAGTAAATAGCTATGTTCCATCAAAAGGAGATATCGTGTGGTTCGATTTTGATCCTTCAGCAGGAAAAGAAAT
TCAAAAAAGAAGACCAGCATTAGTCGTATCAAGACATGATTTTAATCGAACGACAGGATTTGCTATTGTGTGTCCAATTA
CAACAACACAGCTTAATTATCCAACAAGGGTTCAATTGCCCCATATGATAAAAACAAAGGGTCAAATTGTTATTCCACAA
TTAAAATCGTTGGACTTCAATAGTAGACAAGTAGAATTCATTGAAAAGTTGCCTGAAGGGTATATTCAAAGAGTCGATCA
AATTATTCAATATATTTTTAATTAG
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231841 WP_006396780.1 NZ_CP090765:907846-908700 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231841 NZ_CP126962:c1169158-1168928 [Globicatella sanguinis]
ATGTTAACAACTAAAACAAGAACACAAGGCAATTCAATCGTAGTAACTTTACCAGTAGCTGAAAATATAGAATTACAAAG
TCAAAAGGAGTATTTTGTTACTTATCTAGATGATGGGAGTATTATTTTGACGCCTAAAGTTGAAGATCCATTTTTGGTAG
CTGAAGATGGTGCCTATTACGAAGCGGAAGTGTTAGAAGGTATACCAACTTCAGGAAATGAGGTATGGTAA
ATGTTAACAACTAAAACAAGAACACAAGGCAATTCAATCGTAGTAACTTTACCAGTAGCTGAAAATATAGAATTACAAAG
TCAAAAGGAGTATTTTGTTACTTATCTAGATGATGGGAGTATTATTTTGACGCCTAAAGTTGAAGATCCATTTTTGGTAG
CTGAAGATGGTGCCTATTACGAAGCGGAAGTGTTAGAAGGTATACCAACTTCAGGAAATGAGGTATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|