Detailed information of TA system TA231841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 906953..908700
• Replicon: chromosome
• Accession: NZ_CP090765
• Organism: Burkholderia multivorans strain 2008Ycf542

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: L0Y85_RS03905
• Protein ID: WP_105836409.1
• Coordinates: 906953..907849 (+)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: B9AZJ2
• Locus tag: L0Y85_RS03910
• Protein ID: WP_006396780.1
• Coordinates: 907846..908700 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y85_RS03875 (L0Y85_03875)	902353..903432	-	1080	WP_039217461.1	porin	-
L0Y85_RS03880 (L0Y85_03880)	903868..904185	+	318	WP_006396774.1	non-heme iron oxygenase ferredoxin subunit	-
L0Y85_RS03885 (L0Y85_03885)	904187..904498	+	312	WP_006396775.1	hypothetical protein	-
L0Y85_RS03890 (L0Y85_03890)	904546..905616	+	1071	WP_175848021.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
L0Y85_RS03895 (L0Y85_03895)	905609..906379	+	771	WP_006413827.1	SDR family oxidoreductase	-
L0Y85_RS03900 (L0Y85_03900)	906407..906934	+	528	WP_006396778.1	cupin domain-containing protein	-
L0Y85_RS03905 (L0Y85_03905)	906953..907849	+	897	WP_105836409.1	alpha/beta fold hydrolase	Toxin
L0Y85_RS03910 (L0Y85_03910)	907846..908700	+	855	WP_006396780.1	IclR family transcriptional regulator	Antitoxin
L0Y85_RS03915 (L0Y85_03915)	908697..909494	+	798	WP_006396781.1	SDR family oxidoreductase	-
L0Y85_RS03920 (L0Y85_03920)	909487..911154	+	1668	WP_249458835.1	thiamine pyrophosphate-binding protein	-
L0Y85_RS03925 (L0Y85_03925)	911147..911977	+	831	WP_105836412.1	aspartate dehydrogenase	-
L0Y85_RS03930 (L0Y85_03930)	912035..913525	+	1491	WP_043278809.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-280)

Antitoxin

• Transcription regulator IclR, N-terminal (23-71)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30543.77 Da
• Isoelectric Point: 8.0534

>T231841 WP_105836409.1 NZ_CP090765:906953-907849 [Burkholderia multivorans]
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA

Nucleotide

• Length: 897 bp

>T231841 NZ_CP126962:c1168928-1168584 [Globicatella sanguinis]
ATGTTAGAAGTAAATAGCTATGTTCCATCAAAAGGAGATATCGTGTGGTTCGATTTTGATCCTTCAGCAGGAAAAGAAAT
TCAAAAAAGAAGACCAGCATTAGTCGTATCAAGACATGATTTTAATCGAACGACAGGATTTGCTATTGTGTGTCCAATTA
CAACAACACAGCTTAATTATCCAACAAGGGTTCAATTGCCCCATATGATAAAAACAAAGGGTCAAATTGTTATTCCACAA
TTAAAATCGTTGGACTTCAATAGTAGACAAGTAGAATTCATTGAAAAGTTGCCTGAAGGGTATATTCAAAGAGTCGATCA
AATTATTCAATATATTTTTAATTAG

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31176.75 Da
• Isoelectric Point: 6.6558

>AT231841 WP_006396780.1 NZ_CP090765:907846-908700 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 855 bp

>AT231841 NZ_CP126962:c1169158-1168928 [Globicatella sanguinis]
ATGTTAACAACTAAAACAAGAACACAAGGCAATTCAATCGTAGTAACTTTACCAGTAGCTGAAAATATAGAATTACAAAG
TCAAAAGGAGTATTTTGTTACTTATCTAGATGATGGGAGTATTATTTTGACGCCTAAAGTTGAAGATCCATTTTTGGTAG
CTGAAGATGGTGCCTATTACGAAGCGGAAGTGTTAGAAGGTATACCAACTTCAGGAAATGAGGTATGGTAA

Structures

Antitoxin

• AlphaFold DB: B9AZJ2