Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 611086..612385 | Replicon | chromosome |
Accession | NZ_CP090765 | ||
Organism | Burkholderia multivorans strain 2008Ycf542 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | L0Y85_RS02625 | Protein ID | WP_105835289.1 |
Coordinates | 611086..611697 (-) | Length | 204 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | L0Y85_RS02630 | Protein ID | WP_039216965.1 |
Coordinates | 611828..612385 (-) | Length | 186 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Y85_RS02605 (L0Y85_02605) | 606415..607206 | + | 792 | WP_035955458.1 | enoyl-CoA hydratase | - |
L0Y85_RS02610 (L0Y85_02610) | 607203..608342 | + | 1140 | WP_035955456.1 | enoyl-CoA hydratase/isomerase family protein | - |
L0Y85_RS02615 (L0Y85_02615) | 608389..609309 | - | 921 | WP_006406123.1 | LysR family transcriptional regulator | - |
L0Y85_RS02620 (L0Y85_02620) | 609488..611026 | + | 1539 | WP_105810115.1 | MFS transporter | - |
L0Y85_RS02625 (L0Y85_02625) | 611086..611697 | - | 612 | WP_105835289.1 | HD domain-containing protein | Toxin |
L0Y85_RS02630 (L0Y85_02630) | 611828..612385 | - | 558 | WP_039216965.1 | helix-turn-helix transcriptional regulator | Antitoxin |
L0Y85_RS02635 (L0Y85_02635) | 612895..614298 | + | 1404 | WP_006396486.1 | hypothetical protein | - |
L0Y85_RS02640 (L0Y85_02640) | 614640..615371 | + | 732 | WP_012216547.1 | ribonuclease T2 | - |
L0Y85_RS02645 (L0Y85_02645) | 615433..616065 | - | 633 | WP_105835291.1 | isochorismatase family cysteine hydrolase | - |
L0Y85_RS02650 (L0Y85_02650) | 616622..617218 | + | 597 | WP_244131027.1 | Crp/Fnr family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22627.45 Da Isoelectric Point: 5.5913
>T231839 WP_105835289.1 NZ_CP090765:c611697-611086 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMVLVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRDELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTRTHRA
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMVLVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRDELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTRTHRA
Download Length: 612 bp
>T231839 NZ_CP126958:1930436-1930690 [Aerococcus sp. UMB0080]
ATGGAAGTCCATTGGAGTAAGCGGGCGGTCATTGAAAGAGATTATTGGAAAGCTCATGACCCTAAAACCTACAACAAGCT
CTATAAGCTTCTACGAGCGATTAAAGAAGATCCCTACCAGGGCTTAGGTAAACCGGAACCCCTTAAATATGATCTGACCG
GTTACTGGTCCCGCAGACTAAGCAGACAGGTCCGCTTAGTCTACCGAATAAAGGCATCTGCTATTGAGGTCCTATCTTGT
AAGTACCATTATTAA
ATGGAAGTCCATTGGAGTAAGCGGGCGGTCATTGAAAGAGATTATTGGAAAGCTCATGACCCTAAAACCTACAACAAGCT
CTATAAGCTTCTACGAGCGATTAAAGAAGATCCCTACCAGGGCTTAGGTAAACCGGAACCCCTTAAATATGATCTGACCG
GTTACTGGTCCCGCAGACTAAGCAGACAGGTCCGCTTAGTCTACCGAATAAAGGCATCTGCTATTGAGGTCCTATCTTGT
AAGTACCATTATTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20377.36 Da Isoelectric Point: 8.5509
>AT231839 WP_039216965.1 NZ_CP090765:c612385-611828 [Burkholderia multivorans]
MPDSPLHTPPLGPQLRRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
MPDSPLHTPPLGPQLRRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
Download Length: 558 bp
>AT231839 NZ_CP126958:1930191-1930436 [Aerococcus sp. UMB0080]
ATGGAAATTACTAATTATAGTGACTTTAGACAAAATATGAAAAAATATATGGATGTCATTAATGAAGACTCTGTCGAATA
TACGGTCACTTCACAAAACGGTAATGATGTCGTCGTCATGTCAAAATCGGATTTTGATAGCTTAATGGAAACCTACCATC
TCCTTTCTAGTCGAGCCAATCGTGAAAACCTCTACCAAGCCATGGAAGAACTTGACCAGGGCGATTATGAAGTTGAGGAG
ATATAA
ATGGAAATTACTAATTATAGTGACTTTAGACAAAATATGAAAAAATATATGGATGTCATTAATGAAGACTCTGTCGAATA
TACGGTCACTTCACAAAACGGTAATGATGTCGTCGTCATGTCAAAATCGGATTTTGATAGCTTAATGGAAACCTACCATC
TCCTTTCTAGTCGAGCCAATCGTGAAAACCTCTACCAAGCCATGGAAGAACTTGACCAGGGCGATTATGAAGTTGAGGAG
ATATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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