Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 611086..612385 Replicon chromosome
Accession NZ_CP090765
Organism Burkholderia multivorans strain 2008Ycf542

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y85_RS02625 Protein ID WP_105835289.1
Coordinates 611086..611697 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y85_RS02630 Protein ID WP_039216965.1
Coordinates 611828..612385 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y85_RS02605 (L0Y85_02605) 606415..607206 + 792 WP_035955458.1 enoyl-CoA hydratase -
L0Y85_RS02610 (L0Y85_02610) 607203..608342 + 1140 WP_035955456.1 enoyl-CoA hydratase/isomerase family protein -
L0Y85_RS02615 (L0Y85_02615) 608389..609309 - 921 WP_006406123.1 LysR family transcriptional regulator -
L0Y85_RS02620 (L0Y85_02620) 609488..611026 + 1539 WP_105810115.1 MFS transporter -
L0Y85_RS02625 (L0Y85_02625) 611086..611697 - 612 WP_105835289.1 HD domain-containing protein Toxin
L0Y85_RS02630 (L0Y85_02630) 611828..612385 - 558 WP_039216965.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y85_RS02635 (L0Y85_02635) 612895..614298 + 1404 WP_006396486.1 hypothetical protein -
L0Y85_RS02640 (L0Y85_02640) 614640..615371 + 732 WP_012216547.1 ribonuclease T2 -
L0Y85_RS02645 (L0Y85_02645) 615433..616065 - 633 WP_105835291.1 isochorismatase family cysteine hydrolase -
L0Y85_RS02650 (L0Y85_02650) 616622..617218 + 597 WP_244131027.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22627.45 Da        Isoelectric Point: 5.5913

>T231839 WP_105835289.1 NZ_CP090765:c611697-611086 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMVLVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRDELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTRTHRA

Download         Length: 612 bp

>T231839 NZ_CP126958:1930436-1930690 [Aerococcus sp. UMB0080]
ATGGAAGTCCATTGGAGTAAGCGGGCGGTCATTGAAAGAGATTATTGGAAAGCTCATGACCCTAAAACCTACAACAAGCT
CTATAAGCTTCTACGAGCGATTAAAGAAGATCCCTACCAGGGCTTAGGTAAACCGGAACCCCTTAAATATGATCTGACCG
GTTACTGGTCCCGCAGACTAAGCAGACAGGTCCGCTTAGTCTACCGAATAAAGGCATCTGCTATTGAGGTCCTATCTTGT
AAGTACCATTATTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20377.36 Da        Isoelectric Point: 8.5509

>AT231839 WP_039216965.1 NZ_CP090765:c612385-611828 [Burkholderia multivorans]
MPDSPLHTPPLGPQLRRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231839 NZ_CP126958:1930191-1930436 [Aerococcus sp. UMB0080]
ATGGAAATTACTAATTATAGTGACTTTAGACAAAATATGAAAAAATATATGGATGTCATTAATGAAGACTCTGTCGAATA
TACGGTCACTTCACAAAACGGTAATGATGTCGTCGTCATGTCAAAATCGGATTTTGATAGCTTAATGGAAACCTACCATC
TCCTTTCTAGTCGAGCCAATCGTGAAAACCTCTACCAAGCCATGGAAGAACTTGACCAGGGCGATTATGAAGTTGAGGAG
ATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References