Detailed information of TA system TA231838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 282295..282890
• Replicon: chromosome
• Accession: NZ_CP090765
• Organism: Burkholderia multivorans strain 2008Ycf542

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: L0Y85_RS01185
• Protein ID: WP_105834886.1
• Coordinates: 282295..282645 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: L0Y85_RS01190
• Protein ID: WP_105834901.1
• Coordinates: 282639..282890 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y85_RS01175 (L0Y85_01175)	277385..280570	+	3186	WP_249458849.1	multidrug efflux RND transporter permease subunit CeoB	-
L0Y85_RS01180 (L0Y85_01180)	280581..282116	+	1536	WP_249458847.1	multidrug efflux transporter outer membrane subunit OpcM	-
L0Y85_RS01185 (L0Y85_01185)	282295..282645	-	351	WP_105834886.1	type II toxin-antitoxin system ChpB family toxin	Toxin
L0Y85_RS01190 (L0Y85_01190)	282639..282890	-	252	WP_105834901.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
L0Y85_RS01195 (L0Y85_01195)	283443..284936	-	1494	WP_105834887.1	M81 family metallopeptidase	-
L0Y85_RS01200 (L0Y85_01200)	285037..286341	-	1305	WP_039222447.1	MFS transporter	-
L0Y85_RS01205 (L0Y85_01205)	286483..287454	+	972	WP_006397255.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12356.39 Da
• Isoelectric Point: 10.4367

>T231838 WP_105834886.1 NZ_CP090765:c282645-282295 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTATQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Nucleotide

• Length: 351 bp

>T231838 NZ_CP126958:1844440-1844718 [Aerococcus sp. UMB0080]
ATGTACAAAGTCAAGTTCACGAACGCTTATAAGAAAAGCTATAAGCGCATGTTTAAACGTGGAGTCGATCTCTCCCTCTT
AGATGAAGTGGTTGATAACTTAAGGCGAGGTATTCAACTTGATCCTAGATACAAAAACCACATGCTAAAAGGAAAGTTCT
CCGGTTACTTTGAGTGTCACATTAAACCGGATTGGTTACTCATTTATCTGATAGAAGATGATATTCTTACCCTCACGCTT
ATCGATACAGGTAGTCACTCAGATCTATTCAACCTATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8993.33 Da
• Isoelectric Point: 6.2420

>AT231838 WP_105834901.1 NZ_CP090765:c282890-282639 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMGAWGEVKPVGR
EAW

Nucleotide

• Length: 252 bp

>AT231838 NZ_CP126958:1844165-1844440 [Aerococcus sp. UMB0080]
GTGGCAACAAGTCCTACTCAAATTCGTATTGATGCTAAAGTCAAATCAGAAGCAAATGAACTTTTCAATGAACTTGGCAT
TGATATGTCTAGTGCCGTAAACATGTTCTTGCGTCAGTGCATTCTACGTGGTGGTCTTCCTTTTAGCGTGGAACTTCCTC
GATTCAATGAAGCTACCCTAAATGCGATGGCGGAGGCTAGAAGAGTTTCCAGAGATCCTGACACACCCTCTTATTCTTCT
ATGGAAGAGCTAAAGAAAGCACTACTGTCTGAGTGA