Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2353297..2354523 Replicon chromosome
Accession NZ_CP090764
Organism Burkholderia cenocepacia strain 2008Ycf657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z06_RS31470 Protein ID WP_205671284.1
Coordinates 2353942..2354523 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z06_RS31465 Protein ID WP_006483170.1
Coordinates 2353297..2353863 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z06_RS31440 (L0Z06_31440) 2348690..2349325 + 636 WP_205671283.1 isochorismatase family cysteine hydrolase -
L0Z06_RS31445 (L0Z06_31445) 2349351..2350082 - 732 WP_006498851.1 ribonuclease T2 -
L0Z06_RS31450 (L0Z06_31450) 2350118..2350702 + 585 WP_227739690.1 OsmC family protein -
L0Z06_RS31455 (L0Z06_31455) 2350781..2351353 - 573 WP_006498849.1 hypothetical protein -
L0Z06_RS31460 (L0Z06_31460) 2351447..2352850 - 1404 WP_077056620.1 hypothetical protein -
L0Z06_RS31465 (L0Z06_31465) 2353297..2353863 + 567 WP_006483170.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z06_RS31470 (L0Z06_31470) 2353942..2354523 + 582 WP_205671284.1 HD domain-containing protein Toxin
L0Z06_RS31475 (L0Z06_31475) 2355192..2355950 + 759 WP_205671285.1 DUF3658 domain-containing protein -
L0Z06_RS31480 (L0Z06_31480) 2356159..2357349 + 1191 WP_060263806.1 efflux RND transporter periplasmic adaptor subunit -
L0Z06_RS31485 (L0Z06_31485) 2357352..2359385 + 2034 WP_048986896.1 MacB family efflux pump subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2347821..2355950 8129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21339.91 Da        Isoelectric Point: 4.9572

>T231837 WP_205671284.1 NZ_CP090764:2353942-2354523 [Burkholderia cenocepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAARDEIVALWDEYEAATSPEARAAKALDKLETILQHNQGNNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

>T231837 NZ_CP126958:c1842898-1842653 [Aerococcus sp. UMB0080]
ATGGAAGTAACGAATTACAGTGATTTTAGGCAAAATATGAAACATTACATGGATCAGATTAATGAGGATGCCATTGAATA
TACTGTCACATCTCAGAACGGCAATGATGTGGTTGTGATGGCTAAATCCGATTTCGATAGTTTGATGGAGACTTATCATC
TCTTATCCAGTCGTGCTAACCGTGAGAACCTCTATCAAGCCATGGATGAACTCGATCGTGGCGATTATGAAGTTGAGGAG
ATCTGA

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20583.56 Da        Isoelectric Point: 10.7753

>AT231837 WP_006483170.1 NZ_CP090764:2353297-2353863 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp

>AT231837 NZ_CP126958:c1842653-1842399 [Aerococcus sp. UMB0080]
ATGAAAGTTCATTGGAGTCGACGGTCTGTGATTGAACGCGAGGCCTGGAGAGAAAATGATCAAAAAGTTTATGATAAAAT
CTACCGCCTCTTGCGAGCCATTAAAGAAGACCCATACCAAGGCTTAGGTAAGCCGGAGCCCTTGAAGTATGACCTATCTG
GCTATTGGTCACGACGGCTGACGAGACAAGATCGCTTAGTCTATCGCGTCACAGACGATGCCATTGAAGTCCTGTCTTGC
AAATACCATTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References