Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1995747..1997539 | Replicon | chromosome |
| Accession | NZ_CP090764 | ||
| Organism | Burkholderia cenocepacia strain 2008Ycf657 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | L0Z06_RS29840 | Protein ID | WP_205670554.1 |
| Coordinates | 1996643..1997539 (-) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A364H4C6 |
| Locus tag | L0Z06_RS29835 | Protein ID | WP_006496928.1 |
| Coordinates | 1995747..1996604 (-) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z06_RS29815 (L0Z06_29815) | 1990910..1992400 | - | 1491 | WP_006487205.1 | aldehyde dehydrogenase | - |
| L0Z06_RS29820 (L0Z06_29820) | 1992473..1993300 | - | 828 | WP_034202181.1 | aspartate dehydrogenase | - |
| L0Z06_RS29825 (L0Z06_29825) | 1993293..1994960 | - | 1668 | WP_205670553.1 | thiamine pyrophosphate-binding protein | - |
| L0Z06_RS29830 (L0Z06_29830) | 1994953..1995750 | - | 798 | WP_034202180.1 | SDR family oxidoreductase | - |
| L0Z06_RS29835 (L0Z06_29835) | 1995747..1996604 | - | 858 | WP_006496928.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z06_RS29840 (L0Z06_29840) | 1996643..1997539 | - | 897 | WP_205670554.1 | alpha/beta fold hydrolase | Toxin |
| L0Z06_RS29845 (L0Z06_29845) | 1997558..1998085 | - | 528 | WP_006489904.1 | cupin domain-containing protein | - |
| L0Z06_RS29850 (L0Z06_29850) | 1998120..1998890 | - | 771 | WP_080322526.1 | SDR family oxidoreductase | - |
| L0Z06_RS29855 (L0Z06_29855) | 1998883..1999953 | - | 1071 | WP_006489909.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z06_RS29860 (L0Z06_29860) | 2000008..2000319 | - | 312 | WP_006489911.1 | hypothetical protein | - |
| L0Z06_RS29865 (L0Z06_29865) | 2000321..2000638 | - | 318 | WP_006489883.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z06_RS29870 (L0Z06_29870) | 2001083..2002162 | + | 1080 | WP_006489902.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30585.83 Da Isoelectric Point: 7.7324
>T231836 WP_205670554.1 NZ_CP090764:c1997539-1996643 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWLRQLDTLGASRRVLAW
DAPGYGVSTPVHGVSPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWLRQLDTLGASRRVLAW
DAPGYGVSTPVHGVSPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA
Download Length: 897 bp
>T231836 NZ_CP126958:c1842653-1842399 [Aerococcus sp. UMB0080]
ATGAAAGTTCATTGGAGTCGACGGTCTGTGATTGAACGCGAGGCCTGGAGAGAAAATGATCAAAAAGTTTATGATAAAAT
CTACCGCCTCTTGCGAGCCATTAAAGAAGACCCATACCAAGGCTTAGGTAAGCCGGAGCCCTTGAAGTATGACCTATCTG
GCTATTGGTCACGACGGCTGACGAGACAAGATCGCTTAGTCTATCGCGTCACAGACGATGCCATTGAAGTCCTGTCTTGC
AAATACCATTATTAA
ATGAAAGTTCATTGGAGTCGACGGTCTGTGATTGAACGCGAGGCCTGGAGAGAAAATGATCAAAAAGTTTATGATAAAAT
CTACCGCCTCTTGCGAGCCATTAAAGAAGACCCATACCAAGGCTTAGGTAAGCCGGAGCCCTTGAAGTATGACCTATCTG
GCTATTGGTCACGACGGCTGACGAGACAAGATCGCTTAGTCTATCGCGTCACAGACGATGCCATTGAAGTCCTGTCTTGC
AAATACCATTATTAA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31371.86 Da Isoelectric Point: 6.5061
>AT231836 WP_006496928.1 NZ_CP090764:c1996604-1995747 [Burkholderia cenocepacia]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT231836 NZ_CP126958:c1842898-1842653 [Aerococcus sp. UMB0080]
ATGGAAGTAACGAATTACAGTGATTTTAGGCAAAATATGAAACATTACATGGATCAGATTAATGAGGATGCCATTGAATA
TACTGTCACATCTCAGAACGGCAATGATGTGGTTGTGATGGCTAAATCCGATTTCGATAGTTTGATGGAGACTTATCATC
TCTTATCCAGTCGTGCTAACCGTGAGAACCTCTATCAAGCCATGGATGAACTCGATCGTGGCGATTATGAAGTTGAGGAG
ATCTGA
ATGGAAGTAACGAATTACAGTGATTTTAGGCAAAATATGAAACATTACATGGATCAGATTAATGAGGATGCCATTGAATA
TACTGTCACATCTCAGAACGGCAATGATGTGGTTGTGATGGCTAAATCCGATTTCGATAGTTTGATGGAGACTTATCATC
TCTTATCCAGTCGTGCTAACCGTGAGAACCTCTATCAAGCCATGGATGAACTCGATCGTGGCGATTATGAAGTTGAGGAG
ATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|