Detailed information of TA system TA231835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1751752..1752391
• Replicon: chromosome
• Accession: NZ_CP090764
• Organism: Burkholderia cenocepacia strain 2008Ycf657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z06_RS28755
• Protein ID: WP_006481544.1
• Coordinates: 1751752..1752168 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: L0Z06_RS28760
• Protein ID: WP_006481537.1
• Coordinates: 1752155..1752391 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z06_RS28730 (L0Z06_28730)	1746859..1747959	-	1101	WP_062885552.1	nitronate monooxygenase	-
L0Z06_RS28735 (L0Z06_28735)	1747956..1748876	-	921	WP_006481536.1	enoyl-CoA hydratase	-
L0Z06_RS28740 (L0Z06_28740)	1748885..1749682	-	798	WP_006481539.1	hypothetical protein	-
L0Z06_RS28745 (L0Z06_28745)	1749693..1750586	-	894	WP_062885556.1	CoA-transferase	-
L0Z06_RS28750 (L0Z06_28750)	1750596..1751492	-	897	WP_058903174.1	VOC family protein	-
L0Z06_RS28755 (L0Z06_28755)	1751752..1752168	-	417	WP_006481544.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z06_RS28760 (L0Z06_28760)	1752155..1752391	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
L0Z06_RS28765 (L0Z06_28765)	1752884..1754110	+	1227	WP_205670521.1	acyltransferase	-
L0Z06_RS28770 (L0Z06_28770)	1754121..1754798	-	678	WP_077176171.1	hypothetical protein	-
L0Z06_RS28775 (L0Z06_28775)	1755447..1756220	-	774	WP_077189415.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15402.64 Da
• Isoelectric Point: 6.8818

>T231835 WP_006481544.1 NZ_CP090764:c1752168-1751752 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T231835 NZ_CP126958:1221510-1221842 [Aerococcus sp. UMB0080]
ATGGTAAAAGTGAAGCAGGGATCGATTATCAAGATAAATTTAGACCCGAAACAGGGACATGAACAAAAAGGCTATCGGCC
CTACATTTGTTTGAGCCATGGTATTGTTACTAAGTACTCAAATATTGCAATTTTTGCACCCATTAGTCATACAAAAAGAA
AATATCCATTTTATGTTGAGTTAGAACAAACAAAAACGACTGGAAAAGTGCTATTAGATCAATTAGTTACCATCGATTTT
AATGCCAGAGACTATAAGTATATCGAACAAGTTCCAGATGATATACTCATTGATTTATTAGCTAGGGTAAAAGTTCTATT
TGAAAAAGAATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT231835 WP_006481537.1 NZ_CP090764:c1752391-1752155 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT231835 NZ_CP126958:1221271-1221516 [Aerococcus sp. UMB0080]
ATGCCTTTAACAATTAATAAATGGGGGAATAGTTCTGCTATTCGACTTCCAAAACAATTACTTGAAGAACTCAATCTATC
CCAAGGCGACAAACTAGATTATCAGGTAAAAGATGGCCAGCTGATTATAAAAAAAATAACCGAAGTTCCTGAACTTACGG
TTAAAGACTTGTTTGAAAATTATGATGGAGATCCTGTTAATGAAAAGCCGCAATTATTTGAACAAAAAGGAAATGAAAAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A364H554