Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1236151..1236797 Replicon chromosome
Accession NZ_CP090764
Organism Burkholderia cenocepacia strain 2008Ycf657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z06_RS26500 Protein ID WP_109342384.1
Coordinates 1236390..1236797 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag L0Z06_RS26495 Protein ID WP_006491146.1
Coordinates 1236151..1236393 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z06_RS26480 (L0Z06_26480) 1232146..1233552 + 1407 WP_111441417.1 aspartate ammonia-lyase -
L0Z06_RS26485 (L0Z06_26485) 1233630..1235135 + 1506 WP_006491141.1 amino acid permease -
L0Z06_RS26490 (L0Z06_26490) 1235209..1235892 - 684 WP_111441416.1 phospholipase -
L0Z06_RS26495 (L0Z06_26495) 1236151..1236393 + 243 WP_006491146.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z06_RS26500 (L0Z06_26500) 1236390..1236797 + 408 WP_109342384.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z06_RS26505 (L0Z06_26505) 1236914..1237102 - 189 WP_240465729.1 hypothetical protein -
L0Z06_RS26510 (L0Z06_26510) 1237199..1239574 + 2376 WP_111441414.1 MCP four helix bundle domain-containing protein -
L0Z06_RS26515 (L0Z06_26515) 1239597..1240325 + 729 WP_111441422.1 methyl-accepting chemotaxis protein -
L0Z06_RS26520 (L0Z06_26520) 1240322..1240903 + 582 WP_069353548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14945.06 Da        Isoelectric Point: 6.3763

>T231834 WP_109342384.1 NZ_CP090764:1236390-1236797 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARHLVLVTHNVREFERVPRLQFEDWLAEPRAD

Download         Length: 408 bp

>T231834 NZ_CP126956:17967-18116 [Escherichia coli O78:H4]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT231834 WP_006491146.1 NZ_CP090764:1236151-1236393 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp

>AT231834 NZ_CP126956:c17923-17862 [Escherichia coli O78:H4]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References