Detailed information of TA system TA231832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3426062..3426699
• Replicon: chromosome
• Accession: NZ_CP090763
• Organism: Burkholderia cenocepacia strain 2008Ycf657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z06_RS20570
• Protein ID: WP_205671571.1
• Coordinates: 3426062..3426463 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: L0Z06_RS20575
• Protein ID: WP_034201144.1
• Coordinates: 3426463..3426699 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z06_RS20560 (L0Z06_20560)	3423446..3424576	+	1131	WP_085964363.1	alginate lyase family protein	-
L0Z06_RS20565 (L0Z06_20565)	3424607..3425995	+	1389	WP_077190293.1	L-serine ammonia-lyase	-
L0Z06_RS20570 (L0Z06_20570)	3426062..3426463	-	402	WP_205671571.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z06_RS20575 (L0Z06_20575)	3426463..3426699	-	237	WP_034201144.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z06_RS20580 (L0Z06_20580)	3426817..3427046	-	230	Protein_3157	type II toxin-antitoxin system RelE/ParE family toxin	-
L0Z06_RS20585 (L0Z06_20585)	3427415..3429118	+	1704	WP_205671570.1	thiamine pyrophosphate-binding protein	-
L0Z06_RS20590 (L0Z06_20590)	3429115..3430212	+	1098	WP_200063711.1	ADP-heptose--LPS heptosyltransferase	-
L0Z06_RS20595 (L0Z06_20595)	3430307..3431323	-	1017	WP_006493582.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15039.29 Da
• Isoelectric Point: 6.2245

>T231832 WP_205671571.1 NZ_CP090763:c3426463-3426062 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFARCYTGDVVMSAITYAELECGLTACVNPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T231832 NZ_CP126955:4981974-4982360 [Escherichia coli O78:H4]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT231832 WP_034201144.1 NZ_CP090763:c3426699-3426463 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT231832 NZ_CP126955:4981435-4981944 [Escherichia coli O78:H4]
ATGGCATATCTGAAATTGATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9