Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2245493..2246134 Replicon chromosome
Accession NZ_CP090761
Organism Burkholderia cenocepacia strain 2009Ycf95III

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L0Z39_RS30790 Protein ID WP_276209001.1
Coordinates 2245493..2245831 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L0Z39_RS30795 Protein ID WP_062885379.1
Coordinates 2245835..2246134 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z39_RS30780 (L0Z39_30780) 2242023..2243456 - 1434 WP_006490987.1 aldehyde dehydrogenase family protein -
L0Z39_RS30785 (L0Z39_30785) 2243485..2245125 - 1641 WP_006490980.1 acetolactate synthase large subunit -
L0Z39_RS30790 (L0Z39_30790) 2245493..2245831 + 339 WP_276209001.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z39_RS30795 (L0Z39_30795) 2245835..2246134 + 300 WP_062885379.1 putative addiction module antidote protein Antitoxin
L0Z39_RS30800 (L0Z39_30800) 2246183..2247469 - 1287 WP_006490986.1 DUF445 domain-containing protein -
L0Z39_RS30805 (L0Z39_30805) 2247579..2248799 - 1221 WP_205670709.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z39_RS30810 (L0Z39_30810) 2248789..2249115 - 327 WP_006496019.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z39_RS30815 (L0Z39_30815) 2249151..2249627 - 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z39_RS30820 (L0Z39_30820) 2249643..2250914 - 1272 WP_205670708.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(17-109)

Antitoxin

(4-97)


Sequences


Toxin        


Download         Length: 113 a.a.        Molecular weight: 12604.50 Da        Isoelectric Point: 7.8496

>T231830 WP_276209001.1 NZ_CP090761:2245493-2245831 [Burkholderia cenocepacia]
MVYTLQCMPYSPPAFGIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRG
TIWVILLCGGDQSTQQADIRAAHAMLAYLDME

Download         Length: 339 bp

>T231830 NZ_CP126955:c4299221-4298694 [Escherichia coli O78:H4]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10622.07 Da        Isoelectric Point: 6.4771

>AT231830 WP_062885379.1 NZ_CP090761:2245835-2246134 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHAAKAAA

Download         Length: 300 bp

>AT231830 NZ_CP126955:c4299494-4299228 [Escherichia coli O78:H4]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References