Detailed information of TA system TA231829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1886507..1887153
• Replicon: chromosome
• Accession: NZ_CP090761
• Organism: Burkholderia cenocepacia strain 2009Ycf95III

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z39_RS29255
• Protein ID: WP_109342384.1
• Coordinates: 1886507..1886914 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B4EGU8
• Locus tag: L0Z39_RS29260
• Protein ID: WP_006491146.1
• Coordinates: 1886911..1887153 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z39_RS29235 (L0Z39_29235)	1882401..1882982	-	582	WP_069353548.1	hypothetical protein	-
L0Z39_RS29240 (L0Z39_29240)	1882979..1883707	-	729	WP_111441422.1	methyl-accepting chemotaxis protein	-
L0Z39_RS29245 (L0Z39_29245)	1883730..1886105	-	2376	WP_111441414.1	MCP four helix bundle domain-containing protein	-
L0Z39_RS29250 (L0Z39_29250)	1886202..1886390	+	189	WP_240465729.1	hypothetical protein	-
L0Z39_RS29255 (L0Z39_29255)	1886507..1886914	-	408	WP_109342384.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z39_RS29260 (L0Z39_29260)	1886911..1887153	-	243	WP_006491146.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z39_RS29265 (L0Z39_29265)	1887412..1888095	+	684	WP_111441416.1	phospholipase	-
L0Z39_RS29270 (L0Z39_29270)	1888169..1889674	-	1506	WP_006491141.1	amino acid permease	-
L0Z39_RS29275 (L0Z39_29275)	1889752..1891158	-	1407	WP_111441417.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14945.06 Da
• Isoelectric Point: 6.3763

>T231829 WP_109342384.1 NZ_CP090761:c1886914-1886507 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARHLVLVTHNVREFERVPRLQFEDWLAEPRAD

Nucleotide

• Length: 408 bp

>T231829 NZ_CP126955:3982338-3982802 [Escherichia coli O78:H4]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.02 Da
• Isoelectric Point: 5.0197

>AT231829 WP_006491146.1 NZ_CP090761:c1887153-1886911 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Nucleotide

• Length: 243 bp

>AT231829 NZ_CP126955:3982003-3982338 [Escherichia coli O78:H4]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: B4EGU8