Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1370926..1371565 Replicon chromosome
Accession NZ_CP090761
Organism Burkholderia cenocepacia strain 2009Ycf95III

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z39_RS27005 Protein ID WP_006481544.1
Coordinates 1371149..1371565 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A364H554
Locus tag L0Z39_RS27000 Protein ID WP_006481537.1
Coordinates 1370926..1371162 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z39_RS26985 (L0Z39_26985) 1367097..1367870 + 774 WP_077189415.1 SDR family oxidoreductase -
L0Z39_RS26990 (L0Z39_26990) 1368519..1369196 + 678 WP_077176171.1 hypothetical protein -
L0Z39_RS26995 (L0Z39_26995) 1369207..1370433 - 1227 WP_205670521.1 acyltransferase -
L0Z39_RS27000 (L0Z39_27000) 1370926..1371162 + 237 WP_006481537.1 DNA-binding protein Antitoxin
L0Z39_RS27005 (L0Z39_27005) 1371149..1371565 + 417 WP_006481544.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z39_RS27010 (L0Z39_27010) 1371825..1372721 + 897 WP_058903174.1 VOC family protein -
L0Z39_RS27015 (L0Z39_27015) 1372731..1373624 + 894 WP_062885556.1 CoA-transferase -
L0Z39_RS27020 (L0Z39_27020) 1373635..1374432 + 798 WP_006481539.1 hypothetical protein -
L0Z39_RS27025 (L0Z39_27025) 1374441..1375361 + 921 WP_006481536.1 enoyl-CoA hydratase -
L0Z39_RS27030 (L0Z39_27030) 1375358..1376458 + 1101 WP_062885552.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15402.64 Da        Isoelectric Point: 6.8818

>T231828 WP_006481544.1 NZ_CP090761:1371149-1371565 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Download         Length: 417 bp

>T231828 NZ_CP126955:c3862183-3861887 [Escherichia coli O78:H4]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8710.78 Da        Isoelectric Point: 5.0916

>AT231828 WP_006481537.1 NZ_CP090761:1370926-1371162 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT231828 NZ_CP126955:c3861885-3861490 [Escherichia coli O78:H4]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H554

References