Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 768794..770020 Replicon chromosome
Accession NZ_CP090761
Organism Burkholderia cenocepacia strain 2009Ycf95III

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z39_RS24290 Protein ID WP_205671284.1
Coordinates 768794..769375 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z39_RS24295 Protein ID WP_006483170.1
Coordinates 769454..770020 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z39_RS24275 (L0Z39_24275) 763932..765965 - 2034 WP_048986896.1 MacB family efflux pump subunit -
L0Z39_RS24280 (L0Z39_24280) 765968..767158 - 1191 WP_060263806.1 efflux RND transporter periplasmic adaptor subunit -
L0Z39_RS24285 (L0Z39_24285) 767367..768125 - 759 WP_205671285.1 DUF3658 domain-containing protein -
L0Z39_RS24290 (L0Z39_24290) 768794..769375 - 582 WP_205671284.1 HD domain-containing protein Toxin
L0Z39_RS24295 (L0Z39_24295) 769454..770020 - 567 WP_006483170.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z39_RS24300 (L0Z39_24300) 770467..771870 + 1404 WP_077056620.1 hypothetical protein -
L0Z39_RS24305 (L0Z39_24305) 771964..772536 + 573 WP_006498849.1 hypothetical protein -
L0Z39_RS24310 (L0Z39_24310) 772615..773199 - 585 WP_227739690.1 OsmC family protein -
L0Z39_RS24315 (L0Z39_24315) 773235..773966 + 732 WP_006498851.1 ribonuclease T2 -
L0Z39_RS24320 (L0Z39_24320) 773992..774627 - 636 WP_205671283.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21339.91 Da        Isoelectric Point: 4.9572

>T231826 WP_205671284.1 NZ_CP090761:c769375-768794 [Burkholderia cenocepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAARDEIVALWDEYEAATSPEARAAKALDKLETILQHNQGNNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

>T231826 NZ_CP126955:c3617166-3616759 [Escherichia coli O78:H4]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20583.56 Da        Isoelectric Point: 10.7753

>AT231826 WP_006483170.1 NZ_CP090761:c770020-769454 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp

>AT231826 NZ_CP126955:c3617413-3617147 [Escherichia coli O78:H4]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References