Detailed information of TA system TA231824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 85491..86128
• Replicon: chromosome
• Accession: NZ_CP090760
• Organism: Burkholderia cenocepacia strain 2009Ycf95III

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z39_RS04815
• Protein ID: WP_205671571.1
• Coordinates: 85727..86128 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: L0Z39_RS04810
• Protein ID: WP_034201144.1
• Coordinates: 85491..85727 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z39_RS04790 (L0Z39_04790)	80867..81883	+	1017	WP_006493582.1	helix-turn-helix domain-containing protein	-
L0Z39_RS04795 (L0Z39_04795)	81978..83075	-	1098	WP_200063711.1	ADP-heptose--LPS heptosyltransferase	-
L0Z39_RS04800 (L0Z39_04800)	83072..84775	-	1704	WP_205671570.1	thiamine pyrophosphate-binding protein	-
L0Z39_RS04805 (L0Z39_04805)	85144..85373	+	230	Protein_71	type II toxin-antitoxin system RelE/ParE family toxin	-
L0Z39_RS04810 (L0Z39_04810)	85491..85727	+	237	WP_034201144.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z39_RS04815 (L0Z39_04815)	85727..86128	+	402	WP_205671571.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z39_RS04820 (L0Z39_04820)	86195..87583	-	1389	WP_077190293.1	L-serine ammonia-lyase	-
L0Z39_RS04825 (L0Z39_04825)	87614..88744	-	1131	WP_085964363.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15039.29 Da
• Isoelectric Point: 6.2245

>T231824 WP_205671571.1 NZ_CP090760:85727-86128 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFARCYTGDVVMSAITYAELECGLTACVNPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T231824 NZ_CP126955:c3406301-3405990 [Escherichia coli O78:H4]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT231824 WP_034201144.1 NZ_CP090760:85491-85727 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT231824 NZ_CP126955:c3405993-3405574 [Escherichia coli O78:H4]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9