Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1953503..1954123 Replicon chromosome
Accession NZ_CP090758
Organism Burkholderia multivorans strain 2010Ycf31III

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z13_RS27195 Protein ID WP_012217495.1
Coordinates 1953503..1953820 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z13_RS27200 Protein ID WP_006398012.1
Coordinates 1953824..1954123 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z13_RS27185 (L0Z13_27185) 1950038..1951471 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Z13_RS27190 (L0Z13_27190) 1951500..1953140 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z13_RS27195 (L0Z13_27195) 1953503..1953820 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z13_RS27200 (L0Z13_27200) 1953824..1954123 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z13_RS27205 (L0Z13_27205) 1954156..1955442 - 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Z13_RS27210 (L0Z13_27210) 1955557..1956777 - 1221 WP_006411378.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z13_RS27215 (L0Z13_27215) 1956767..1957093 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z13_RS27220 (L0Z13_27220) 1957111..1957599 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z13_RS27225 (L0Z13_27225) 1957614..1958885 - 1272 WP_006411366.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231823 WP_012217495.1 NZ_CP090758:1953503-1953820 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231823 NZ_CP126955:c3175135-3174737 [Escherichia coli O78:H4]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231823 WP_006398012.1 NZ_CP090758:1953824-1954123 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231823 NZ_CP126955:c3175362-3175135 [Escherichia coli O78:H4]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References