Detailed information of TA system TA231821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1227163..1227697
• Replicon: chromosome
• Accession: NZ_CP090758
• Organism: Burkholderia multivorans strain 2010Ycf31III

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Z13_RS24005
• Protein ID: WP_006411826.1
• Coordinates: 1227163..1227462 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: L0Z13_RS24010
• Protein ID: WP_006397060.1
• Coordinates: 1227452..1227697 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z13_RS23990 (L0Z13_23990)	1222740..1223867	-	1128	WP_006403536.1	VOC family protein	-
L0Z13_RS23995 (L0Z13_23995)	1224222..1225529	+	1308	WP_006411823.1	shikimate transporter	-
L0Z13_RS24000 (L0Z13_24000)	1225753..1227054	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Z13_RS24005 (L0Z13_24005)	1227163..1227462	-	300	WP_006411826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z13_RS24010 (L0Z13_24010)	1227452..1227697	-	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Z13_RS24015 (L0Z13_24015)	1227837..1228607	+	771	WP_006403543.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Z13_RS24020 (L0Z13_24020)	1228646..1230946	-	2301	WP_006411821.1	ATP-dependent DNA helicase	-
L0Z13_RS24025 (L0Z13_24025)	1230943..1232646	-	1704	WP_006411824.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11585.15 Da
• Isoelectric Point: 9.3671

>T231821 WP_006411826.1 NZ_CP090758:c1227462-1227163 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231821 NZ_CP126955:c2642798-2642544 [Escherichia coli O78:H4]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT231821 WP_006397060.1 NZ_CP090758:c1227697-1227452 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231821 NZ_CP126955:c2643046-2642795 [Escherichia coli O78:H4]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: B9B0C2