Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2071014..2071595 Replicon chromosome
Accession NZ_CP090757
Organism Burkholderia multivorans strain 2010Ycf31III

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L0Z13_RS12490 Protein ID WP_035946056.1
Coordinates 2071014..2071307 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J4SGI3
Locus tag L0Z13_RS12495 Protein ID WP_006409266.1
Coordinates 2071311..2071595 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z13_RS12470 (L0Z13_12470) 2066503..2067603 - 1101 WP_006404967.1 chorismate synthase -
L0Z13_RS12475 (L0Z13_12475) 2067772..2069706 - 1935 WP_006404968.1 MFS transporter -
L0Z13_RS12480 (L0Z13_12480) 2069855..2070310 - 456 WP_006402096.1 CBS domain-containing protein -
L0Z13_RS12485 (L0Z13_12485) 2070471..2070788 + 318 WP_006402097.1 DUF962 domain-containing protein -
L0Z13_RS12490 (L0Z13_12490) 2071014..2071307 + 294 WP_035946056.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z13_RS12495 (L0Z13_12495) 2071311..2071595 + 285 WP_006409266.1 putative addiction module antidote protein Antitoxin
L0Z13_RS12500 (L0Z13_12500) 2071607..2071867 + 261 WP_226823124.1 hypothetical protein -
L0Z13_RS12505 (L0Z13_12505) 2072031..2073359 - 1329 WP_045594112.1 YihY family inner membrane protein -
L0Z13_RS12510 (L0Z13_12510) 2073504..2074115 + 612 WP_006402099.1 NAD(P)H:quinone oxidoreductase -
L0Z13_RS12515 (L0Z13_12515) 2074112..2074507 + 396 WP_006404970.1 DUF2069 domain-containing protein -
L0Z13_RS12520 (L0Z13_12520) 2074526..2075947 + 1422 WP_043279886.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-88)

Antitoxin

Uncharacterized protein HI1420

(5-90)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11168.92 Da        Isoelectric Point: 9.4615

>T231816 WP_035946056.1 NZ_CP090757:2071014-2071307 [Burkholderia multivorans]
MVTLLRSTEFNDWLANLRDQRGKARIAARLISAQLGNFGEYRVLDEGVCELKIDFGPGYRVYYVRRGEVVYLLLCGGDKS
TQRKDIKPVQMARELKE

Download         Length: 294 bp

>T231816 NZ_CP126955:c1807507-1807400 [Escherichia coli O78:H4]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 9986.38 Da        Isoelectric Point: 6.2121

>AT231816 WP_006409266.1 NZ_CP090757:2071311-2071595 [Burkholderia multivorans]
MTNYTEFDAADYLDNDEAVAEFLAVAAEDPNPDVFLAAVAAVARARGMTKVAAAAGVGRVALHKALTPGAHPRYETVQKI
IRSLGLRMSFTVAH

Download         Length: 285 bp

>AT231816 NZ_CP126955:1807560-1807621 [Escherichia coli O78:H4]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J4SGI3

References